Taylor, Philip - Cardiff University

个人简介

Education and qualifications 1998 PhD Molecular Genetics, Imperial College London. 1994 BSc Human Genetics, University College London. Career overview 2016- Wellcome Trust Investigator Cardiff Institute of Infection and Immunity, Cardiff University. 2012- Professor of Translational Immunology Cardiff Institute of Infection and Immunity, Cardiff University. 2007-2012 Medical Research Council Senior Research Fellowship/Reader Department of Infection, Immunity and Biochemistry, Cardiff University. 2006-2007 Wellcome Trust Research Career Development Fellowship Department of Medical Biochemistry and Immunology, Cardiff University. 2003-2006 Wellcome Trust Research Career Development Fellowship Sir William Dunn School of Pathology, Oxford University. 1999-2002 Wellcome Trust Postdoctoral Research Associate Sir William Dunn School of Pathology, Oxford University. 1998-1999 Wellcome Trust Postdoctoral Research Associate Hammersmith Hospital, Imperial College School of Medicine, London. 1997-1998 Arthritis Research Campaign Postdoctoral Research Associate Hammersmith Hospital, Imperial College School of Medicine, London.

研究领域

Research is carried out under the umbrella of the ‘Myeloid Cell Biology’ Group (led by Prof. Taylor and Dr. Selinda Orr (Wellcome Trust funded Sir Henry Dale Fellow). The Myeloid Cell Biology group is interested primarily in macrophages, but also dendritic cells and neutrophils. These cells are phagcocytes, specialised blood cells, which ingest other cells (both microbial and self) as well as foreign particles. Phagocytes have diverse roles during development, host defence, inflammation (mediation and resolution), wound healing, immune surveillance and alteration of the adaptive immune response. Professional phagocytes are defined by their expression of a diverse array of receptors for recognising invading organisms such as bacteria and fungi, dead and dying cells, abnormal host cells and environmental particles. These receptors are ‘opsonic’, such as the Fc and complement receptors, and ‘non-opsonic’, such as the Toll-like receptors, and specific cell surface lectins. The Myeloid Cell Biology group is primarily interested in fundamental aspects of phagocyte biology, such as the receptors used to recognise pathogens, the signalling molecules involved in the subsequent downstream cellular activation events and fundamental aspects of cell biology such as the regulation of apoptosis or cell renewal. Understanding, how phagocytes respond to specific challenges presents an opportunity to manipulate the behaviour of cells at the very heart of innate and adaptive immunity.

近期论文

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Liao, C.et al. 2017. Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney International (10.1016/j.kint.2016.10.030) pdf Perks, W.et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186(11), pp. 2813-2823. (10.1016/j.ajpath.2016.07.021) pdf Liao, C.et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528) pdf Patin, E.et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197(1), pp. 208-221. (10.4049/jimmunol.1501204) pdf Liao, C.et al. 2015. Deciphering the peritoneal mononuclear phagocyte system in mice: Steady state and inflammation [Poster abstract]. Nephrology Dialysis Transplantation 30(iii), pp. iii265. (10.1093/ndt/gfv180.25) Liao, C.et al. 2015. Determining the identity and functional specialization of peritoneal mononuclear phagocytes in peritoneal dialysis patients. Nephrology Dialysis Transplantation 30(S3), article number: iii264. (10.1093/ndt/gfv180.21) Jenkins, R.et al. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30(iii262) (10.1093/ndt/gfv180.15) Davies, L. C. and Taylor, P. R. 2015. Tissue-resident macrophages: then and now. Immunology 144(4), pp. 541-548. (10.1111/imm.12451) Veninga, H.et al. 2015. Antigen targeting reveals splenic CD169+macrophages as promoters of germinal center B-cell responses. European Journal of Immunology 45(3), pp. 747-757. (10.1002/eji.201444983) Stack, G.et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11(2), article number: e1004641. (10.1371/journal.ppat.1004641) pdf Liddiard, K. and Taylor, P. R. 2015. Understanding local macrophage phenotypes in disease: shape-shifting macrophages. Nature Medicine 21(2), pp. 119-120. (10.1038/nm.3798)