个人简介

B.S., University of Arizona, 1974 Ph.D., Michigan State, 1979

研究领域

Analytical

Analytical mass spectrometry Research in our group centers around three aspects of analytical mass spectrometry and related techniques: instrumentation, fundamentals, and applications. Instrumentation development includes projects in tandem mass spectrometry (MS/MS) and ion mobility, including the development of the first laser microprobe MS/MS system able to image trace levels of drugs and biomolecules in tissue specimens. Fundamental studies in our group employ both experiment and computer modeling/simulation to explore such issues as ion motion and ion-molecule interactions in high-field ion mobility. Applications of the techniques developed in our group include a wide range of studies in clinical, pharmacological, biotechnological, environmental, and forensic analysis.

近期论文

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"Ionization Sources and Mass Analyzers in Imaging Mass Spectrometry", Y. Tsai, R. F. Menger, T. J. Garrett, R. A. Yost, D. M. Dexler, Chapter in Imaging Mass Spectrometry Technologies, Future Sciences, in press (2014). "Direct lipid profiling of single neurons and neuronal compartments", M. P. Napolitano, L.L. Moroz, R.A. Yost, Nature Sci. Reports, in press (2014). "Fundamental Studies of the Role of Solvent Vapor in FAIMS", L.C. Rorrer III and R.A. Yost, Int. J. Mass Spectrom., in press (2014). "Performance Enhancement in the Measurement of 5 Endogenous Steroids in Human Serum by LC-MS/MS Combined with Differential Ion Mobility Spectrometry", J.A. Ray, M.M. Kushnir, R.A. Yost, A.L. Rockwood, and A.W. Meikle, Clin. Chim. Acta, 438, 330-336 (2015). "Standardized Method for Solubility and Storage of Capsaicin-based Solutions for Cough Induction", M. Costanzo, P. Davenport, and RA. Yost, Cough, 10:6 doi: 10.1186/1745-9974-10-6 (2014). "Isotopic Ratio Outlier Analysis Global Metabolomics of Caenorhabditis elegans", G. S. Stupp,C.S. Clendinen, R.Ajredini, M.A. Szewc, T. Garrett, R.F. Menger, R. A. Yost, C.Beecher, A. S. Edison, Anal.Chem., 85, 11858-11865 (2013). "MALDI Mass Spectrometric Imaging of Caenorhabditis elegans", R.F. Menger, C.S. Clendinen, A.S. Edson and R.A. Yost, Anal. Chem., 85, 11858-11865 (2013). "Characterization of Phosphatidylcholine Oxidation Products by MALDI MS", W.L Stutts, R. F. Menger, A. Kiss, R.M.A. Heeren, R. A. Yost, Anal. Chem. 85, 11410-11419 (2013). "Jim Morrison, Friend and Colleague", C.G. Enke and R.A. Yost, J. Amer. Soc. Mass Spectrom. 24, 1319-1323 (2013). "Identifying Tissue-Specific Signal Variation in MALDI Mass Spectrometric Imaging using an Internal Standard", D.A. Pirman, A. Kiss,R.M.A. Heeren, and R.A. Yost, Anal. Chem., 85, 1090–1096 (2013). "Quantitative MALDI Tandem Mass Spectrometric Imaging of Cocaine from Brain Tissue with a Deuterated Internal Standard", D.A. Pirman, R.F. Reich, A. Kiss, R.M.A. Heeren, and R.A. Yost, Anal. Chem., 85, 1081–1089 (2013). "Foreword", R.A. Yost, Handbook of Mass Spectrometry, MS Lee, ed., John Wiley & Sons, p. xi, (2012). "High-Field Asymmetric Waveform Ion Mobility Spectrometry with Solvent Vapor Addition: A Potentially Greener Analytical Technique for Bioanalysis", C-W. Tsai, R.A. Yost, and T.J Garrett, Bioanalysis, 4, 1363-1375 (2012). "MALDI Mass Spectrometric Imaging of Cardiac Tissue Following Myocardial Infarction in a Rat Coronary Artery Ligation Model", R.F. Menger, W.L. Stutts, D. Anbukumar, J.A. Bowden, D.A. Ford, and R.A. Yost, Anal. Chem., 84, 1117-1125 (2012). "Comparison of Rectangular and Bisinusoidal Waveforms in a Miniature Planar High-Field Asymmetric Waveform Ion Mobility Spectrometer", M. Prieto, C-W. Tsai, S. Boumsellek, R. Ferran, I. Kaminsky, S. Harris, and R.A. Yost, Anal. Chem., 83, 9237-9243 (2011). "Mass Spectrometric Imaging for Drug Distribution in Tissues", D.P Magparangalan, T.J. Garrett, D.M. Drexler, and R.A. Yost, Chapter 26 in ADME-Enabling Technologies for Drug Design and Development, D. Zhang and S. Surapaneni, ed., John Wiley & Sons, (2012), pp. 401-417. "Quantitative Tandem Mass Spectrometric Imaging of Endogenous Acetyl-l-Carnitine from Piglet Brain Tissue Using an Internal Standard", D.A. Pirman, P.R. Borum, and R.A. Yost, Anal. Chem., 83, 8575-8581 (2011). "Characterization of Protonated Phospholipids as Fragile Ions in Ion Trap Mass Spectrometry", T.J. Garrett, M.M Merves, and R.A. Yost, Int. J. Mass Spectrom., 308, 299-306 (2011). "Direct Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Imaging of Cellulose and Hemicelluloses in Populus Tissue", K.A. Lunsford, G.F. Peter, and R.A. Yost, Anal. Chem.,83, 6722-6730 (2011). "Quantification of Lipids in Nerve Tissue Using MALDI Mass Spectrometric Imaging", R.R. Landgraf, M.C. Prieto-Conway, T.J. Garrett, P.W. Stacpoole, and R.A. Yost, Rapid Commun. Mass Spectrom., 25, 3178-3184 (2011).