O'Donnell, Valerie - Cardiff University

个人简介

Education: 1993 PhD Bristol University, Biochemistry 1990 BSc, University of Dublin, Trinity College, Human Nutrition and Dietetics

研究领域

Our research uses mass spectrometry to discover and characterise new lipids (fats) made by circulating vascular cells that regulate immune defence and blood clotting. Recently we showed that human blood platelets generate a large number of oxidized phospholipids several of which help clotting factors in plasma work more effectively. We also uncovered a new role for phospholipases in providing energy to the cell and how lipids in different people respond individually to aspirin (http://www.cardiff.ac.uk/news/view/264589-understanding-the-bodys-response-to-aspirin) In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research). Our current research is focused on understanding the role of new lipids in vascular inflammation including cardiovascular disease, dementia and wound healing. Some lipids we discovered are being developed as the basis of new treatments for bleeding excess. Research in our group is funded by grants from the European Research Council, Wellcome Trust, British Heart Foundation and Medical Research Council.

近期论文

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Aldrovandi, M.et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001) pdf Heurich-Sevcenco, M.et al. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017) pdf Liao, C.et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528) pdf Stokes, C.et al. 2016. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology 9(5), pp. 1303-1316. (10.1038/mi.2015.137) pdf Chiba, T.et al. 2016. The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate. Journal of Biological Chemistry 291(28), pp. 14540-14544. (10.1074/jbc.M115.711267) pdf Hinz, C.et al. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291(26), pp. 13448-13464. (10.1074/jbc.M115.700609) pdf Slatter, D.et al. 2016. Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation. Cell Metabolism 23(5), pp. 930-944. (10.1016/j.cmet.2016.04.001) pdf Bascoul-Colombo, C.et al. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861, pp. 524-537. (10.1016/j.bbalip.2016.03.005) pdf Jones, V.et al. 2016. Role of Ep2 and Ep4 receptors in airway microvascular leak induced by prostaglandin E2. British Journal of Pharmacology 173(6), pp. 992-1004. (10.1111/bph.13400) pdf Freeman, P.et al. 2015. Changes in platelet function independent of pharmacotherapy following coronary intervention in non-ST-elevation myocardial infarction patients. Atherosclerosis 243(1), pp. 320-327. (10.1016/j.atherosclerosis.2015.09.024) McCully, M.et al. 2015. Skin metabolites define a new paradigm in the localization of skin tropic memory T cells. The Journal of Immunology 195(1), pp. 96-104. (10.4049/jimmunol.1402961) pdf