Man, Stephen - Cardiff University

个人简介

Career Overview 2013-present: Reader, Division of Cancer and Genetics, School of Medicine, Cardiff University 2002-2012: Senior Lecturer, Infection and Immunity, School of Medicine, Cardiff University 1995-2003: Royal Society University Research Fellow, Department of Medicine, University of Wales College of Medicine 1994-1995: Post-doctoral Research Fellow, Department of Medicine, University of Wales College of Medicine 1990-1994: Post-doctoral Research Fellow, Department of Microbiology, University of Virginia, USA

研究领域

My research is focussed on the role of the immune system in cancer, in particular trying to develop new ways to treat cancer or to monitor the status of the immune system to identify poor prognosis patients. Over the last 5 years I have been working in a team dedicated to the study of Chronic Lymphocytic Leukaemia (CLL). My laboratory has three main research topics:

近期论文

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Dockree, T.et al. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95(1), pp. 68-76. (10.1038/icb.2016.85) pdf Parry, H.et al. 2016. Cytomegalovirus infection does not impact on survival or time to first treatment in patients with Chronic Lymphocytic Leukaemia. American Journal of Hematology 91(8), pp. 776-781. (10.1002/ajh.24403) Sacco, J.et al. 2016. Systemic listeriosis following vaccination with the attenuatedListeria monocytogenestherapeutic vaccine, ADXS11-001. Human Vaccines & Immunotherapeutics 12(4), pp. 1085-1086. (10.1080/21645515.2015.1121338) pdf Coles, S.et al. 2015. The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse. Leukemia 29(9), pp. 1952. (10.1038/leu.2015.62) Reid, R.et al. 2015. CD8+ T-cell recognition of a synthetic epitope formed by t-butyl modification. Immunology 144(3), pp. 495-505. (10.1111/imm.12398) pdf Reid, R.et al. 2015. CD8+T-cell recognition of a synthetic epitope formed byt-butyl modification. Immunology 144(3), pp. 495-505. (10.1111/imm.12398) Hurt, C.et al. 2014. Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT³VIN): a multicentre, open-label, randomised, phase 2 trial. Lancet Oncology 15(12), pp. 1361-1368. (10.1016/S1470-2045(14)70456-5) pdf Stanton, R.et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host & Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005) pdf Wong, R.et al. 2013. Blinatumomab induces autologous T cell killing of chronic lymphocytic leukemia cells. Haematologica 98(12), pp. 1930-1938. (10.3324/haematol.2012.082248) Al-Taei, S.et al. 2013. Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy. Cancer Immunology, Immunotherapy 62(12), pp. 1821-1830. (10.1007/s00262-013-1488-5)