Burns, Noah Z. - Stanford University - Department of Chemistry

个人简介

Noah was born in Oakland, CA but grew up in south central Maine. He attended Columbia University in the city of New York where he was mentored by Professor James Leighton. He obtained his Ph.D. with Professor Phil Baran at the Scripps Research Institute in La Jolla, CA and was then an NIH postdoctoral fellow with Professor Eric Jacobsen at Harvard University. He joined the chemistry faculty at Stanford University in the fall of 2012 and was promoted to Associate Professor in 2019. APPOINTMENT Associate Professor Stanford University, Stanford CA 2019 Assistant Professor Stanford University, Stanford CA 2012–2019 EDUCATION AND TRAINING Postdoctoral Fellow (NIH) 2009–2012 Harvard University, Cambridge MA Advisor: Eric N. Jacobsen Doctor of Philosophy The 2004–2009 Scripps Research Institute, La Jolla CA Advisor: Phil S. Baran Thesis: Total Syntheses of Haouamine A Bachelor of Arts, Chemistry 2000–2004 Columbia University, New York NY Advisor: James L. Leighton

研究领域

Research in our group explores the boundaries of modern organic synthesis to enable the more rapid creation of the highest molecular complexity in a predictable and controllable fashion. We are particularly inspired by natural products not only because of their importance as synthetic targets but also due to their ability to serve as invaluable identifiers of unanswered scientific questions. One major focus of our research is selective halogenation of organic molecules. Dihalogenation and halofunctionalization encompass some of the most fundamental transformations in our field, yet methods capable of accessing relevant halogenated motifs in a chemo-, regio-, and enantioselective fashion are lacking. We are also interested in the practical total synthesis of natural products for which there is true impetus for their construction due to unanswered chemical, medicinal, biological, or biophysical questions. We are specifically engaged in the construction of unusual lipids with unanswered questions regarding their physical properties and for which synthesis offers a unique opportunity for study.

近期论文

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“A convenient C–H functionalization platform for pyrroloiminoquinone alkaloid synthesis” Myles W. Smith, Isaac D. Falk, Hideya Ikemoto, and Noah Z. Burns. Tetrahedron. 2019, 75, 3366-3370. Article. Supporting Information. [Invited contribution in honor of Professor Ryan Shenvi, recipient of the 2019 Tetrahedron Young Investigator Award.] 2019 A convenient C–H functionalization platform for pyrroloiminoquinone alkaloid synthesis Tetrahedron_web.png "Enantioselective Synthesis of Azamerone” Matthew L. Landry, Grace M. McKenna, and Noah Z. Burns. J. Am. Chem. Soc. 2019, 141, 2867–2871. Article. Supporting Information. "Catalytic Regio- and Enantioselective Haloazidation of Allylic Alcohols" Frederick J. Seidl, Chang Min, Jovan A. Lopez and Noah Z. Burns. J. Am. Chem. Soc. 2018, 140, 15646-15650. Article. Supporting Information. "Catalytic Regio- and Enantioselective Haloazidation of Allylic Alcohols" Frederick J. Seidl, Chang Min, Jovan A. Lopez and Noah Z. Burns. J. Am. Chem. Soc. 2018, 140, 15646-15650. Article. Supporting Information. "Synthesis and Mechanochemical Activation of Ladderene–Norbornene Block Copolymers" Jessica K. Su, John D. Feist, Jinghui Yang, Jaron A. M. Mercer, Joseph A. H. Romaniuk, Zhixing Chen, Lynette Cegelski, Noah Z. Burns, and Yan Xia. J. Am. Chem. Soc. 2018, 140, 12388-12391. Article. Supporting Information. "Synthesis and Mechanochemical Activation of Ladderene–Norbornene Block Copolymers" Jessica K. Su, John D. Feist, Jinghui Yang, Jaron A. M. Mercer, Joseph A. H. Romaniuk, Zhixing Chen, Lynette Cegelski, Noah Z. Burns, and Yan Xia. J. Am. Chem. Soc. 2018, 140, 12388-12391. Article. Supporting Information. "Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability" Frank R. Moss III, Steven R. Shuken, Jaron A. M. Mercer, Carolyn M. Cohen, Thomas. M. Weiss, Steven G. Boxer, and Noah Z. Burns. Proc. Natl. Acad. Sci. 2018, 115, 9098-9103. Article. Supporting Information. "Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability" Frank R. Moss III, Steven R. Shuken, Jaron A. M. Mercer, Carolyn M. Cohen, Thomas. M. Weiss, Steven G. Boxer, and Noah Z. Burns. Proc. Natl. Acad. Sci. 2018, 115, 9098-9103. Article. Supporting Information. "Catalytic Enantioselective Dihalogenation in Total Synthesis" Matthew L. Landry, and Noah Z. Burns. Acc. Chem. Res. 2018, 51, 1260–1271. Article. "Catalytic Enantioselective Dihalogenation in Total Synthesis" Matthew L. Landry, and Noah Z. Burns. Acc. Chem. Res. 2018, 51, 1260–1271. Article. "Site-selective bromination of sp3 C–H bonds" Shyam Sathyamoorthi, Shibdas Banerjee, Justin Du Bois, Noah Z. Burns, and Richard N. Zare. Chem. Sci. 2018, 9, 100–104. Article. Supporting Information. "Site-selective bromination of sp3 C–H bonds" Shyam Sathyamoorthi, Shibdas Banerjee, Justin Du Bois, Noah Z. Burns, and Richard N. Zare. Chem. Sci. 2018, 9, 100–104. Article. Supporting Information. "Enantiospecific Solvolytic Functionalization of Bromochlorides" Alexander J. Burckle, Bálint Gál, Frederick J. Seidl, Vasil H. Vasilev, and Noah Z. Burns. J. Am. Chem. Soc. 2017, 139, 13562–13569. Article. Supporting Information. "Enantiospecific Solvolytic Functionalization of Bromochlorides" Alexander J. Burckle, Bálint Gál, Frederick J. Seidl, Vasil H. Vasilev, and Noah Z. Burns. J. Am. Chem. Soc. 2017, 139, 13562–13569. Article. Supporting Information. "Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene" Zhixing Chen, Jaron A. M. Mercer, Xiaolei Zhu, Joseph A. H. Romaniuk, Raphael Pfattner, Lynette Cegelski, Todd J. Martinez, Noah Z. Burns, and Yan Xia. Science 2017, 357, 475–479. Article. Supporting Information. "Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene" Zhixing Chen, Jaron A. M. Mercer, Xiaolei Zhu, Joseph A. H. Romaniuk, Raphael Pfattner, Lynette Cegelski, Todd J. Martinez, Noah Z. Burns, and Yan Xia. Science 2017, 357, 475–479. Article. Supporting Information. "Chemical synthesis and self-assembly of a ladderane phospholipid" Jaron A. M. Mercer, Carolyn M. Cohen, Steven R. Shuken, Anna M. Wagner, Myles W. Smith, Frank R. Moss III, Matthew D. Smith, Riku Vahala, Alejandro Gonzalez-Martinez, Steven G. Boxer, and Noah Z. Burns. J. Am. Chem. Soc. 2016, 138, 15845–15848. Article. Supporting Information. [Featured in the ACS Select Virtual Issue on Total Synthesis of Natural Products: link.] "Chemical synthesis and self-assembly of a ladderane phospholipid" Jaron A. M. Mercer, Carolyn M. Cohen, Steven R. Shuken, Anna M. Wagner, Myles W. Smith, Frank R. Moss III, Matthew D. Smith, Riku Vahala, Alejandro Gonzalez-Martinez, Steven G. Boxer, and Noah Z. Burns. J. Am. Chem. Soc. 2016, 138, 15845–15848. Article. Supporting Information. [Featured in the ACS Select Virtual Issue on Total Synthesis of Natural Products: link .] "Chiral Alkyl Halides: Underexplored Motifs in Medicine" Bálint Gál, Cyril Bucher, Noah Z. Burns. Mar. Drugs 2016, 14, 206. Article. [Invited contribution for Special Issue on Marine Organohalides] "Chiral Alkyl Halides: Underexplored Motifs in Medicine" Bálint Gál, Cyril Bucher, Noah Z. Burns. Mar. Drugs 2016, 14, 206. Article. [Invited contribution for Special Issue on Marine Organohalides] "A Unified Approach for the Enantioselective Synthesis of the Brominated Chamigrene Sesquiterpenes" Alexander J. Burckle, Vasil H. Vasilev, Noah Z. Burns. Angew. Chem. Int. Ed. 2016, 55, 11476–11479. Article. Supporting Information. "A Unified Approach for the Enantioselective Synthesis of the Brominated Chamigrene Sesquiterpenes" Alexander J. Burckle, Vasil H. Vasilev, Noah Z. Burns. Angew. Chem. Int. Ed. 2016, 55, 11476–11479. Article. Supporting Information. "Selective Bromochlorination of a Homoallylic Alcohol for the Total Synthesis of (–)-Anverene" Frederick J. Seidl, Noah Z. Burns. Beilstein J. Org. Chem. 2016, 12, 1361–1365. Article. Supporting Information. [Invited contribution for Special Themed Issue on Strategies in Asymmetric Catalysis] "Selective Bromochlorination of a Homoallylic Alcohol for the Total Synthesis of (–)-Anverene" Frederick J. Seidl, Noah Z. Burns. Beilstein J. Org. Chem. 2016, 12, 1361–1365. Article. Supporting Information. [Invited contribution for Special Themed Issue on Strategies in Asymmetric Catalysis] "Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (–)-Deschloromytilipin A and (–)-Danicalipin A" Matthew L. Landry, Dennis X. Hu, Grace M. McKenna, Noah Z. Burns. J. Am. Chem. Soc. 2016, 138, 5150–5158. Article. Supporting information. "Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (–)-Deschloromytilipin A and (–)-Danicalipin A" Matthew L. Landry, Dennis X. Hu, Grace M. McKenna, Noah Z. Burns. J. Am. Chem. Soc. 2016, 138, 5150–5158. Article. Supporting information. "Natural products: Emulation illuminates biosynthesis" Jaron A. M. Mercer, Noah Z. Burns. Nature Chem. 2015, 7, 860–861. "Highly Selective Synthesis of Halomon, Plocamenone, and Isoplocamenone" Cyril Bucher, Richard M. Deans, Noah Z. Burns. J. Am. Chem. Soc. 2015, 137, 12784–12787. Article. Supporting information. "Highly Selective Synthesis of Halomon, Plocamenone, and Isoplocamenone" Cyril Bucher, Richard M. Deans, Noah Z. Burns. J. Am. Chem. Soc. 2015, 137, 12784–12787. Article. Supporting information. "Catalytic Chemo-, Regio-, and Enantioselective Bromochlorination of Allylic Alcohols" Dennis X. Hu, Fritz J. Seidl, Cyril Bucher, Noah Z. Burns. J. Am. Chem. Soc. 2015, 137, 3795–3798. Article. Supporting information. "Catalytic Chemo-, Regio-, and Enantioselective Bromochlorination of Allylic Alcohols" Dennis X. Hu, Fritz J. Seidl, Cyril Bucher, Noah Z. Burns. J. Am. Chem. Soc. 2015, 137, 3795–3798. Article. Supporting information. "Catalytic Enantioselective Dibromination of Allylic Alcohols" Dennis X. Hu, Grant M. Shibuya, Noah Z. Burns. J. Am. Chem. Soc. 2013, 135, 12960–12963. Article. Supporting information. "Catalytic Enantioselective Dibromination of Allylic Alcohols" Dennis X. Hu, Grant M. Shibuya, Noah Z. Burns. J. Am. Chem. Soc. 2013, 135, 12960–12963. Article. Supporting information. Burns, N. Z.; Jacobsen, E. N. "Catalysis in Tight Spaces," Nature, 2012, 483, 278–279. Burns, N. Z.; Witten, M. W.; Jacobsen, E. N. "Dual Catalysis in Enantioselective Oxidopyrylium-Based [5 + 2] Cycloadditions," J. Am. Chem. Soc. 2011, 133, 14578–14581.