Hoogendoorn, Bastiaan - Cardiff University

个人简介

Education and qualifications 1998: PhD (Molecular Biology) BBSRC/University of Hertfortshire, UK. 1994: BSc & MSc(Plant Pathology/Nematology) Wageningen Agricultural University, Wageningen, The Netherlands. 1984: BSc (Zoology and Microbiology/Plant Pathology) University of Natal, Pietermaritzburg, South Africa. Career overview From 2012 to end 2015 Lecturer in the Infections and Antimicrobial Resistance research theme group in the Institute for Primary Care and Public Health. From January 2006 to Jan 2012 Lecturer at the Centre for Health and Environmental Research in the Institute of Primary Care and Public Health. Before that (from 2003) I was a non-clinical lecturer and Alzheimer’s Society Research Fellow in the Department of Psychological Medicine. I joined the College of Medicine in 1997 as post-doc and in 2000 was awarded a UWCM Senior Research Fellowship.

研究领域

I am a member of the Infections & Antimicrobial Resistance Research Group in the Division of Population Medicine. Research in which I am primarily involved is in infections and the use of novel technologies in the application of point of care tests and the diagnosis and management of infectious conditions. My particular interest is in using genomic and proteomic techniques in the search for clinically relevant mechanisms of host response to infection with antimicrobial resistant bacteria and the identification of useful biomarkers. We are also in the process of developing a point-of-care diagnostic device for the detection of bacterial pneumonia in exhaled breath. This device will be targeted at low and middle income developing countries.

近期论文

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Clark, J.et al. 2016. The biological effects upon the cardiovascular system consequent to exposure to particulates of less than 500 nm in size. Biomarkers 21(1), pp. 1-47. (10.3109/1354750X.2015.1118540) pdf Matthews, I.et al. 2013. Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat. Environmental Toxicology and Pharmacology 35(3), pp. 461-464. (10.1016/j.etap.2013.02.002) Elvidge, T.et al. 2013. Feasibility of using biomarkers in blood serum as markers of effect following exposure of the lungs to particulate matter air pollution [review]. Journal of Environmental Science and Health, Part C 31(1), pp. 1-44. (10.1080/10590501.2013.763575) Van Woerden, H.et al. 2013. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study. BMC Infectious Diseases 13, article number: 69. (10.1186/1471-2334-13-69) pdf Hoogendoorn, B.et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600) Deschepper, M.et al. 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88(2-3), pp. 210-222. (10.1016/j.brainresbull.2011.01.012) Price, H.et al. 2010. Airborne particles in Swansea, UK: their collection and characterization. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 355-367. (10.1080/15287390903442652) Buckland, P.et al. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207) Buckland, P.et al. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613) Buckland, P.et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.