Fraser, Donald - Cardiff University

个人简介

Education and qualifications 2016: GCP (Good Clinical Practise in Research) Certification (Health and Care Research Wales) 2006: Postgraduate Medical Education and Training Board, Certificate of Completion of Training, General (Internal) Medicine and Nephrology 2003: PhD, University of Wales College of Medicine 1996: Member of The Royal College of Physicians, London 1993: MB ChB, University of Bristol Career overview 2015-Present: Professor of Nephrology, Cardiff University School of Medicine 2005-2015: Cardiff University School of Medicine (2005: Lecturer, 2006: Senior Lecturer, 2011: Reader) 1997-2005: Specialist Registrar, All Wales Nephrology and General (Internal) Medicine Rotation 1995-1997: Senior House Officer, South Manchester University Hospitals Rotation 1994-1995: Senior House Officer, Burnley General Hospital 1993-1994: House Physician and Surgeon, Bristol Royal Infirmary and Southmead Hospital, Bristol

研究领域

My research addresses the mechanisms underlying injury and scarring in the kidney and peritoneum, in the contexts of chronic kidney disease and peritoneal dialysis. These are examples of fibro-proliferative disorders, conditions that cause significant disease and suffering, and for which treatment options are very limited. Development and testing of novel therapies is restricted by incomplete knowledge of the biology of their progression, and lack of adequate biomarkers to serve as surrogate endpoints in clinical trials.

近期论文

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Liao, C.et al. 2017. Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney International (10.1016/j.kint.2016.10.030) pdf Liuzzi, A.et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990) pdf Liao, C.et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528) pdf Raby, A.et al. 2016. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology (10.1681/ASN.2015080923) Simpson, K.et al. 2016. MicroRNAs in diabetic nephropathy: from biomarkers to therapy. Current Diabetes Reports 16(3), article number: 35. (10.1007/s11892-016-0724-8) pdf Khalid, U.et al. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30(2), pp. 99-104. (10.1111/ctr.12679) Chavez, R.et al. 2016. Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. Journal of Histology and Histopathology 3, article number: 1. (10.7243/2055-091X-3-1) pdf Beelen, R.et al. 2016. Addressing peritoneal dialysis: in vitro PD models, in vivo rodent PD model, clinical biobanks, and underutilization of PD. BioMed Research International 2016, article number: 4964316. (10.1155/2016/4964316) pdf Raby, A.et al. 2016. Toll-like receptors 2 and 4 are potential therapeutic targets against peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology pdf