Dayan, Colin - Cardiff University

个人简介

Colin Dayan trained in medicine at University College, Oxford, and Guy’s and Charing Cross Hospitals in London, UK before obtaining a PhD in the immunology of Graves’ Disease in Laboratory of Marc Feldmann. He then spent a year as an endocrine fellow at the Massachussetts General Hospital in Boston, USA before completing his specialist training in diabetes and endocrinology as a Lecturer in Bristol. He became a consultant senior lecturer in medicine (diabetes/endocrinology) at the University of Bristol in 1995 and Head of Clinical Research at the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology in Bristol in 2002. In 2010, he was appointed to the Chair of Clinical Diabetes and Metabolism and Head of Section at Cardiff University School of Medicine. He served as Director of the Institute of Molecular and Experimental Medicine in 2011 – 2015.

研究领域

He has a long established interest in translational research in the immunopathology of type 1 diabetes and is currently conducting early phase clinical trials in the development of antigen specific immunotherapy. His clinical interests in diabetes include management of poor compliance in type 1 diabetes, public health measures in the prevention of type 2 diabetes and models of community care in diabetes. He is the lead for diabetes in the Cardiff whole pancreas transplantation programme and with colleagues leads an All Wales anonymised data linkage programme for monitoring childhood type 1 diabetes. He has been part of 2 major EU FP7 programme grants in type 1 diabetes (and coordinator on one), a member of the Juvenile Diabetes Research Foundation Medical and Scientific Committee and the Welsh Diabetes Research Unit. Prof Dayan currently leads the Clinical Engagement and Training Core of the Diabetes UK funded type 1 diabetes UK immunotherapy Consortium which aims to coordinate and support combined efforts to bring immunotherapy for type 1 diabetes into clinical practice, and is Chair of the Type 1 diabetes national Prevention and Therapies Clinical Studies Group. He also has research interests in thyroid disease which include thyroid autoimmunity, thyroid hormone replacement and bioavailability, genetic epidemiology as applied to population variation in thyroid hormone bioavailability and thyroid eye disease. He became secretary of the European Thyroid Association in 2013 and chairs the UK Thyroid Eye Disease Amsterdam Implementation Group.

近期论文

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Korevaar, T.et al. 2016. An invitation to join the consortium on thyroid and pregnancy. Obstetrics and Gynaecology 128(4), pp. 913. (10.1097/AOG.0000000000001670) Tatovic, D.et al. 2016. Stimulated urine C-peptide creatinine ratio vs serum C-peptide level for monitoring of β-cell function in the first year after diagnosis of Type 1 diabetes. Diabetic Medicine 33(11), pp. 1564-1568. (10.1111/dme.13186) Eligar, V.et al. 2016. Thyroxine replacement: a clinical endocrinologists viewpoint. Annals of Clinical Biochemistry 53(4), pp. 421-433. (10.1177/0004563216642255) Arif, S.et al. 2016. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults. Diabetic Medicine (10.1111/dme.13153) Vedhara, K.et al. 2016. Illness beliefs predict mortality in patients with diabetic foot ulcers. PLoS ONE 11(4), pp. e0153315. (10.1371/journal.pone.0153315) pdf Bartalena, L.et al. 2016. The 2016 European Thyroid Association/European Group on Graves' Orbitopathy guidelines for the management of Graves' Orbitopathy. European Thyroid Journal 5(1), pp. 9-26. (10.1159/000443828) Muller, I.et al. 2016. The sodium iodide symporter is unlikely to be a thyroid/breast shared antigen. Journal of Endocrinological Investigation 39(3), pp. 323-331. (10.1007/s40618-015-0368-6) Zhao, X.et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040) pdf Taylor, P.et al. 2016. Paradoxical relationship between body mass index and thyroid hormone levels: a study using Mendelian randomization. Journal of Clinical Endocrinology & Metabolism 101(2), pp. 730-738. (10.1210/jc.2015-3505)