Davies, William - Cardiff University

个人简介

Education and qualifications 2012: Postgraduate Certificate in University Teaching and Learning, Cardiff University, Cardiff, UK 1999-2003: Ph.D (Behavioural Neuroscience) University of Cambridge, Cambridge, UK 1995-1999: M.Biochem. University of Bath, Bath, UK Career Overview 2012-present: Senior Lecturer, Cardiff University, Cardiff, UK 2007-2012: Research Councils UK Fellow in Translational Research in Experimental Medicine, Cardiff University, Cardiff, UK 2006-2007: Wellcome Trust 'Value in People' Postdoctoral Researcher, Cardiff University, Cardiff, UK 2003-2006: Postdoctoral Researcher, Babraham Institute, Cambridge, UK

研究领域

I am interested in the (epi)genetic mechanisms underlying sex differences in brain function and behaviour. My work focusses on the role of genes on the sex chromosomes (i.e. the X and Y), which are asymmetrically inherited between the sexes: females inherit two X chromosomes (one from each parent), whereas males inherit just one X chromosome (invariably from their mother) and a Y chromosome from their father. Principal aims of my research are: a) to elucidate why the sexes are differentially vulnerable to common and disabling disorders such as autism and ADHD, b) to understand the neural and molecular processes that increase the risk for postpartum psychiatric disorders in females, and c) to help develop more effective sex-specific therapies.

近期论文

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Humby, T.et al. 2017. A genetic variant within STS previously associated with inattention in boys with Attention Deficit Hyperactivity Disorder is associated with enhanced cognition in healthy adult males. Brain and Behavior (10.1002/brb3.646) pdf Humby, T.et al. 2016. A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis. Psychoneuroendocrinology 74, pp. 363-370. (10.1016/j.psyneuen.2016.09.019) pdf Davies, W. 2016. Insights into rare diseases from social media surveys. Orphanet Journal of Rare Diseases 11, article number: 151. (10.1186/s13023-016-0532-x) pdf Chatterjee, S., Humby, T. and Davies, W. 2016. Behavioural and psychiatric phenotypes in men and boys with X-linked ichthyosis: evidence from a worldwide online survey. Plos One 11(10), pp. e0164417. (10.1371/journal.pone.0164417) pdf Hinton, R.et al. 2015. Preliminary evidence for aortopathy and an x-linked parent-of-origin effect on aortic valve malformation in a mouse model of Turner syndrome. Journal of Cardiovascular Development and Disease 2(3), pp. 190-199. (10.3390/jcdd2030190) pdf Davies, W. and Duncan, L. 2015. Editorial overview: Behavioral genetics. Current Opinion in Behavioral Sciences 2, pp. v-vii. (10.1016/j.cobeha.2014.12.002) Davies, W.et al. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39(11), pp. 2622-2632. (10.1038/npp.2014.115) pdf Davies, W. 2014. Sex differences in Attention Deficit Hyperactivity Disorder: Candidate genetic and endocrine mechanisms. Frontiers in Neuroendocrinology 35(3), pp. 331-346. (10.1016/j.yfrne.2014.03.003) pdf