个人简介

Lake Forest College, B.A. 2007 The University of Kansas, Ph.D. 2012 Postdoctoral Scholar, Boston University, June 2012 – June 2014

研究领域

Organic

Synthetic Organic Chemistry, Complex Natural Products, Drug-Like Molecules Natural products are prized for the potential as pharmaceutical agents. A common bottleneck toward their application in disease treatment is their limited natural abundance and/or inefficient laboratory synthesis. The Grenning research laboratory aims to design new complexity-generating chemical reactions inspired by bioactive natural products. This strategy will provide rapid access to a variety of structurally complex bioactive molecules with high step-economy. We plan to utilize the reactions developed to prepare collections of natural product inspired molecules and gain insight into their biological activities.

近期论文

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Grenning, A. J.; Boyce, J. Porco Jr., J. A. "Rapid Synthesis of Polyprenylated Acylphloroglucinols Analogs via Dearomative Conjunctive Allylic Alkylation." J. Am. Chem. Soc. 2014, 136, 11799. Screen Shot 2014-12-23 at 8.19.17 PM Grenning, A. J.; Snyder, J. K.; Porco Jr., J. A. Jr. "Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction" Org. Lett. 2014, 16, 792. Grenning, A. J.; Van Allen, C. K.; Maji, T.; Lang, S. B.; Tunge, J. A. "Development of Asymmetric Deacylative Allylation." J. Org. Chem. 2013, 78, 7281. PMID: 23734611. Schmidt, M.; Grenning, A. J.; Tunge, J. A.; "Intercepted Decarboxylative Allylations of Nitroalkanoates" Tetrahedron Lett. 2012, 53, 4494. PMID: 22942479. Chattopadhyay, K.; Fenster, E.; Grenning, A. J.; Tunge, J. A.; "Palladium-Catalyzed Substitution of (Coumarinyl)methyl Acetates with C-, N- and S- Nucleophiles." Beilstein J. Org. Chem. 2012, 8, 1200–1207. PMID: 23019448. Weaver, J. D.; Recio, A.; Grenning, A. J.; Tunge, J. A. "Transition-Metal Catalyzed Decarboxylative Allylation and Benzylation Reactions" Chem. Rev. 2011, 111, 1846. PMCID: PMC3116714. Grenning, A. J.; Tunge, J. A.; "Deacylative Allylation: Allylic alkylation via Retro-Claisen Activation." J. Am. Chem. Soc. 2011, 133, 14785. PMID: 21830777. Screen Shot 2014-12-23 at 8.23.06 PM Grenning, A. J.; Tunge, J. A. "Deacylative allylation: Unsymmetric Bisallylation by a Three-Component Coupling." Angew. Chem. Int. Ed. 2011, 50, 1688. PMID: 21308933. Grenning, A. J.; Tunge, J. A. "Rapid Decarboxylative Allylation of Nitroalkanes." Org. Lett. 2010, 12, 740. PMID: 20088536.