Coffey, Marcus - Cardiff University

研究领域

I am currently the Director of the Teaching Academy in the School of Medicine and I also teach the subject of Pharmacology to our Medical and BSc students. Although we only ever want drugs to have a therapeutic effect in patients, we also have to recognise that all drugs have the potential to cause unwanted side effects. So the more we understand about: the composition of drugs; how they have their effects and how a patient responds to the presence of a drug in their body, the safer prescribing medicines becomes. To more fully understand the actions of drugs in the body, I teach our students everything from cardiac electrophysiology to epigenetics and everything in between. My teaching uses interactive computer animations to help explain scientific processes, plus I give our students hands-on practical experiences of using drugs in clinical scenarios. I am a Senior Fellow of the Higher Education Academy.

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Maskrey, B.et al. 2009. Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase [Addition]. Journal of Biological Chemistry 284(37), pp. 25460. (10.1074/jbc.A611776200) Williams, P.et al. 2005. In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. Blood 106(8), pp. 2737-2743. (10.1182/blood-2005-02-0664) Clark, S.et al. 2005. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. Biochemical Journal 385(3), pp. 815-821. (10.1042/BJ20041353) Coffey, M.et al. 2004. Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor. FEBS Letters 576(1-2), pp. 165-168. (10.1016/j.febslet.2004.09.007) Coffey, M.et al. 2004. Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. Circulation Research 94(12), pp. 1598-1605. (10.1161/01.RES.0000132281.78948.65) pdf Clark, S.et al. 2002. Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. The Journal of Immunology 169(10), pp. 5889-5896. Coffey, M.et al. 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98(14), pp. 8006-8011. (10.1073/pnas.141136098)