Clayton, Aled - Cardiff University

个人简介

Career overview Snr Lecturer (08/2013-present), Division of Cancer & Genetics, Cardiff University Lecturer; (08/2004 to 07/2013), School of Medicine, Cardiff University Research Fellow (01/1999 to 07/2004) School of Medicine, Cardiff University Research Fellow, (10/1996 to 12/1998) School of Medicine, Cardiff University Education & qualifications 1997: PhD (Medicine), Institute of Nephrology, University of Wales College of Medicine. 1998: Diploma in Biomedical methods, University of Wales College of Medicine. 1993: BSc (Hons) Biochemistry, University of Wales College Cardiff

研究领域

We are interested in understanding how cells produce small fat-bubbles (vesicles), and why they seem to do this so extensively. Our studies focus on the role of such bubbles in changing the immediate surroundings of the cancer tissue. it seems these bubbles (exosomes) can interfere with the correct function of immune cells, they can encourage formation of blood vessels, and can hijack other neighbouring cells to behave abnormally- all of these effects assist the growth and ultimate spread of the tumour. We can also detect exosomes in the urine and blood of cancer patients, and we are working hard on developing new methods to isolate exosomes from biological fluids, and to use these as means of discovering new indicators of disease. We have examined the complex array of protein molecules on the vesicles, and are beginning to also look at RNA-molecules, which hide inside the bubble. Together, these studies will provide much needed information about how the cancer cells can dominate and take-over their microenvironments. Learning how to block these effects is likely to be very useful therapeutically. Pperhaps we can also use the presence of exosomes in urine/blood as future tests to support diagnoses and monitoring of cancer.

近期论文

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Al-Taei, S.et al. 2016. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: self-amplifying immunosuppression in cancer. OncoImmunology (10.1080/2162402X.2016.1268308) pdf Welton, J.et al. 2016. Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array. Journal of Extracellular Vesicles 5, article number: 31209. (10.3402/jev.v5.31209) pdf Emanueli, C.et al. 2016. Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: an example of exosome trafficking out of the human heart with potential for cardiac biomarker discovery. PLoS ONE 11(4), article number: e0154274. (10.1371/journal.pone.0154274) pdf Webber, J.et al. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget (10.18632/oncotarget.7716) pdf Clayton, A.et al. 2016. The 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts. Journal of Extracellular Vesicles 5, article number: 30924. (10.3402/jev.v5.30924) pdf Connolly, K.et al. 2015. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. Journal of Extracellular Vesicles 4(s1) (10.3402/jev.v4.29159) pdf Beltrami, C.et al. 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1(2), pp. 151-166. (10.3390/ncrna1020151) Salimu, J.et al. 2015. Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells--A Key Role for Heat-Shock Protein 70 and Receptor CD91. Cancer Immunology Research 3(6), pp. 678-688. (10.1158/2326-6066.CIR-14-0079) Webber, J. P., Yeung, V. and Clayton, A. 2015. Extracellular vesicles as modulators of the cancer microenvironment. Seminars in Cell and Developmental Biology 40, pp. 27-34. (10.1016/j.semcdb.2015.01.013) Welton, J.et al. 2015. Ready-made chromatography columns for extracellular vesicle isolation from plasma. Journal of Extracellular Vesicles 4, article number: 27269. (10.3402/jev.v4.27269)