Buckland, Paul - Cardiff University

研究领域

My PhD research was on the biosynthesis of phenazines by micro-organisms. Although much of this work was synthetic chemistry, it aroused my interests in more biological research. In the department of Medicine, Welsh National School of Medicine, I worked as a protein chemist for 5 years (including 3 months at UCLA School of Medicine under Prof. John Pierce) studying the thyroid stimulating hormone (TSH) receptor, and in particular by photoaffinity labelling the receptor with radio labelled TSH. I was awarded an MRC travelling fellowship in 1985 which I undertook at Brigham and Women’s Hospital, Harvard Medical School, Boston, where I trained in molecular biology. On my return, I took up a lectureship in Psychological Medicine where I studied psychopharmacology at the molecular level, primarily measuring mRNA levels and other indices in animals following treatment with psychotropic drugs. In 1998 I switched fields to molecular genetics and studied polymorphisms which have an effect on gene transcription. In 2001, this work was expanded to include gene copy number polymorphism.

近期论文

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Sutrala, S.et al. 2008. Gene copy number variation in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(5), pp. 606-611. (10.1002/ajmg.b.30645) Buckland, P. R. 2008. Will we ever find the genes for addiction?. Addiction 103(11), pp. 1768-1776. (10.1111/j.1360-0443.2008.02285.x) Sutrala, S.et al. 2007. Gene copy number variation in schizophrenia. Schizophrenia Research 96(1-3), pp. 93-99. (10.1016/j.schres.2007.07.029) Wolstencroft, E.et al. 2007. Endosomal location of dopamine receptors in neuronal cell cytoplasm. Journal of Molecular Histology 38(4), pp. 333-340. (10.1007/s10735-007-9106-5) Khan, I.et al. 2006. In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity.. In silico Biology 6(1-2), pp. 23-34. Buckland, P. R. 2006. The importance and identification of regulatory polymorphisms and their mechanisms of action. Biochimica et Biophysica Acta - Molecular Basis of Disease 1762(1), pp. 17-28. (10.1016/j.bbadis.2005.10.004) Norton, N.et al. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(1), pp. 96-101. (10.1002/ajmg.b.30236) Buckland, P.et al. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207) Bray, N.et al. 2005. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Human Molecular Genetics 14(14), pp. 1947-1954. (10.1093/hmg/ddi199) Buckland, P.et al. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)