Brewis, Ian - Cardiff University

个人简介

EDUCATION AND QUALIFICATIONS 1994 The University of Leeds, PhD in Biochemistry 1989 The University of York, BSc (Hons) Biology (Cell Biology and Biochemistry) CAREER OVERVIEW PRESENT CARDIFF RESPONSIBILITIES AND AFFILIATIONS Since 2016 MSc Medical Research and Innovation Programme Director Since 2016 Based at College level in the College of Biomedical and Life Sciences as part of the Clinical Innovation Hub Since 2015 School of Medicine Divisional Teaching Lead for Clinical Innovation (and previously the TIME Institute) Since 2011 School of Medicine Postgraduate Research (PGR) Representative for Clinical Innovation (and previously the TIME Institute) Since 2011 Central Biotechnology Services (CBS) Operational Director Since 2008 Senior Lecturer

研究领域

My main research interests are the proteomic and functional characterisation of mammalian sperm cells at fertilization which for many years has been in close collaboration with Dr Bart Gadella at Utrecht University, The Netherlands. My preferred career direction and its many commitments have necessitated that my own research has been a minor activity during my time in Cardiff and I am no longer independently research active. My main association with the field is now as an Editorial Board Member for the journal Reproduction (Impact Factor 3.184; since 2013) and formerly I was also an Editorial Board Member (Associate Editor) for Molecular Human Reproduction (Impact Factor 3.943; 2012-2015). Before Cardiff I was a Senior Research Fellow at the University of Birmingham and Birmingham NHS Assisted Conception Unit (2000-2003) and a Postdoctoral Research Associate at the University of Sheffield (1993-2000) and primarily focused on molecular aspects of sperm function. These varied roles also included a wide range of other research projects in reproduction and several years working on commercial projects (and in particular a male fertility test and a study using human stem cell technologies). My PhD (1994) on the biochemistry of mammalian glycolipid anchors was conducted as a Research Assistant at the University of Leeds and also involved spending extended time with collaborators at the University of Dundee. I was a Research Assistant at the University of York (1989-1990) where I investigated the biochemistry of the Fallopian tube with weekly experiments performed in the operating theatres at Hammersmith Hospital. Lastly I also studied for my first degree at the University of York and graduated in 1989 with a BSc (Hons) in Biology (Cell Biology and Biochemistry).

近期论文

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Webber, J.et al. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget (10.18632/oncotarget.7716) pdf Webber, J.et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular & Cellular Proteomics 13(4), pp. 1050-1064. (10.1074/mcp.M113.032136) Alsagaby, S.et al. 2014. Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of Proteome Research 13(11), pp. 5051-5062. (10.1021/pr5002803) Hoogendoorn, B.et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600) Tsai, P.et al. 2012. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. Plos One 7(3), article number: e32603.. (10.1371/journal.pone.0032603) pdf Sexton, K.et al. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855) Welton, J.et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9(6), pp. 1324-1338. (10.1074/mcp.M000063-MCP201) Alnagar, F., Brennan, P. and Brewis, I. A. 2010. Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa. Journal of Andrology 31(4), pp. 393-405. (10.2164/jandrol.109.008383) Brewis, I. A. and Topley, N. 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25(6), pp. 1749-1753. (10.1093/ndt/gfq145) Brennan, P.et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)