Bowen, Derrick - Cardiff University

个人简介

Education and qualifications 1984. PhD (Biochemistry). University of Wales, College Swansea. 1981. BSc First class honours (Biochemistry). University of Wales, College Swansea. Career Overview 2015 - present. Senior Lecturer in Medical Education. Cardiff University School of Medicine. 2001 - 2015. Senior Lecturer in Haematology. Cardiff University School of Medicine. 1992 - 2001. Lecturer in Haematology. Cardiff University School of Medicine. 1989 - 1992. Post-doctoral research assistant. (Human Molecular Genetics). Cardiff University School of Medicine. 1985 - 1989. Post-doctoral research assistant. (Protein Engineering). Bristol Unviersity School of Medicine.

研究领域

I am a senior lecturer in Medical Education. I support diverse aspects of the MBBCh curriculum and postgraduate research within the Medical School. I have a research background in haemostasis in the following areas: (1) the biochemistry and quantitative control of the blood protein von Willebrand factor; (2) the genetics of haemophilia A and the relationship between the genetic cause and the phenotypic severity.

近期论文

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Khanum, F.et al. 2014. Joint health scores in a haemophilia A cohort from Pakistan with minimal or no access to factor VIII concentrate: correlation with thrombin generation and underlying mutation. Haemophilia -Oxford- 20(3), pp. 426-434. (10.1111/hae.12326) Khanum, F.et al. 2014. Characterization of F8 defects in haemophilia A in Pakistan: investigation of correlation between mutation type and the in vitro thrombin generation assay. Haemophilia 20(2), pp. 287-293. (10.1111/hae.12272) Burnett, A.et al. 2013. The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-a-winner comparison. Leukemia 27, pp. 75-81. (10.1038/leu.2012.229) Palmer, E.et al. 2012. Roles of promoter and 3′ untranslated motifs in expression of the human C5a receptor. Molecular Immunology 52(2), pp. 88-95. (10.1016/j.molimm.2012.04.012) Davies, J.et al. 2012. von Willebrand factor: demographics of plasma protein level in a large blood donor cohort from South Wales in the United Kingdom [Letter]. Haemophilia 18(3), pp. e79-e81. (10.1111/j.1365-2516.2012.02782.x) Harris, R., Van Den Berg, C. W. and Bowen, D. J. 2012. ASGR1 and ASGR2, the genes that encode the asialoglycoprotein receptor (Ashwell receptor), are expressed in peripheral blood monocytes and show interindividual differences in transcript profile. Molecular Biology International 2012 (10.1155/2012/283974) pdf Bowen, D. J. 2010. Sugar targets VWF for the chop (Comment on McGrath et al). Blood 115(13), pp. 2565. (10.1182/blood-2009-12-256925) Sutherland, M.et al. 2009. A novel deletion mutation is recurrent in von Willebrand disease types 1 and 3. Blood 114(5), pp. 1091-1098. (10.1182/blood-2008-08-173278)