Bowen, Timothy - Cardiff University

个人简介

Tissue engineering and repair expertise Core Nephrology research themes include determination of the pathophysiological mechanisms underlying renal fibrosis and the progression of chronic kidney disease. Fibrosis is associated with increased cortical synthesis of hyaluronan, a glycosaminoglycan of the extracellular matrix. Our work focuses on the regulation of gene expression in renal disease and current areas of interest include: Transcriptional regulation of the genes encoding the human hyaluronan synthases, as well as other fibrosis-associated genes including noncoding RNAs HAS2-AS1 and microRNA-192 Post-transcriptional regulation of the human hyaluronan synthase 2 (HAS2) gene by its natural antisense RNA, HAS2-AS1 Post-transcriptional regulation of fibrosis-associated genes by microRNAs Analysis of urinary microRNAs as candidate biomarkers for chronic kidney disease Interaction of gene expression and cell phenotype, and the effects of this interaction on the progression of renal disease

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Liuzzi, A.et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990) pdf Martin, J.et al. 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation.. Journal of Biological Chemistry 291(26), pp. 13789-13801. (10.1074/jbc.M115.670521) pdf Simpson, K.et al. 2016. MicroRNAs in diabetic nephropathy: from biomarkers to therapy. Current Diabetes Reports 16(3), article number: 35. (10.1007/s11892-016-0724-8) pdf Khalid, U.et al. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30(2), pp. 99-104. (10.1111/ctr.12679) Chavez, R.et al. 2016. Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. Journal of Histology and Histopathology 3, article number: 1. (10.7243/2055-091X-3-1) pdf Khalid, U.et al. 2015. Urinary microrna expression predicts delayed graft function in kidney transplantation [Abstract]. Transplant International 28(S4), pp. 367-367. (10.1111/tri.12702) Beltrami, C.et al. 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1(2), pp. 151-166. (10.3390/ncrna1020151) Jenkins, R.et al. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30(iii262) (10.1093/ndt/gfv180.15) Williams, A., Meran, S. and Bowen, T. 2015. Regulation of synthesis and roles of hyaluronan in peritoneal dialysis. BioMed Research International 2015, article number: 427038. (10.1155/2015/427038) pdf Vigetti, D.et al. 2014. Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation. Journal of Biological Chemistry 289(42), pp. 28816-28826. (10.1074/jbc.M114.597401) Khalid, U.et al. 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42(4), pp. 1219-1223. (10.1042/BST20140093)