Watson, Peter - Cardiff University - School of Biosciences

个人简介

I attained my first degree in Medical Biochemistry from the University of Birmingham, and gained my PhD under the supervision of Professor John Davey at the University of Warwick, studying the pheromone communication pathway of fission yeast. Staying at the University of Warwick, in 2000 I started studying toxin trafficking within the labs of Professors Mike Lord and Lynne Roberts, and during this time I was lucky enough to be trained in light microscopy by Dr. Jez Simpson and Dr. Rainer Pepperkok at EMBL in Heidelberg. Towards the end of 2003 I moved to the lab of Dr. David Stephens at the University of Bristol, where I used both light and electron microscopy to look at how proteins exit the ER and are moved throughout the cell in membranous transport carriers. In February 2007 I moved to the School of Biosciences at Cardiff University to take up an RCUK Fellowship in Translational Research in Experimental Medicine.

研究领域

How mammalian cells regulate and spatially co-ordinate the process of moving cellular cargo, while ensuring that organelle homeostasis, is maintained and cargos are delivered correctly, is the focus of my research. Using small molecule inhibitors, toxins, and classical cell biology, and utilising both fluorescence and non-linear optical approaches, I study the pathways with which mammalian cells are able to move proteins,lipids and nanoparticles between cellular compartments.

近期论文

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Di Napoli, C.et al. 2016. Quantitative spatio-temporal chemical profiling of individual lipid droplets by hyperspectral CARS microscopy in living human adipose-derived stem cells. Analytical Chemistry 88(7), pp. 3677-3685. (10.1021/acs.analchem.5b04468) pdf Moody, P.et al. 2015. Receptor crosslinking – a general method to trigger internalisation and lysosomal targeting of therapeutic receptor:ligand complexes. Molecular Therapy 23(12), pp. 1888-1898. (10.1038/mt.2015.178) pdf Reddington, S.et al. 2015. Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein. RSC Advances 5(95), pp. 77734-77738. (10.1039/C5RA13552D) pdf He, L., Watson, P. D. and Jones, A. T. 2015. Visualizing actin architectures in cells incubated with cell-penetrating peptides. Methods in Molecular Biology 1324, pp. 247-259. (10.1007/978-1-4939-2806-4_16) pdf Sayers, E.et al. 2014. Distal phenylalanine modification for enhancing cellular delivery of fluorophores, proteins and quantum dots by cell penetrating peptides. Journal of Controlled Release 195, pp. 55-62. (10.1016/j.jconrel.2014.07.055) pdf Pope, I.et al. 2014. Coherent anti-Stokes Raman scattering microscopy of single nanodiamonds. Nature Nanotechnology 9(11), pp. 940-946. (10.1038/nnano.2014.210) pdf Di Napoli, C.et al. 2014. Hyperspectral and differential CARS microscopy for quantitative chemical imaging in human adipocytes. Biomedical Optics Express 5(5), pp. 1378-1390. (10.1364/BOE.5.001378) pdf Reddington, S.et al. 2013. Different photochemical events of a genetically encoded phenyl azide define and modulate GFP fluorescence. Angewandte Chemie - International Edition 52(23), pp. 5974-5977. (10.1002/anie.201301490) Pope, I.et al. 2013. Simultaneous hyperspectral differential-CARS, TPF and SHG microscopy with a single 5 fs Ti:Sa laser. Optics Express 21(6), pp. 7096-7106. (10.1364/OE.21.007096) pdf