Smalley, Matt - Cardiff University - School of Biosciences

研究领域

My group is trying to understand how the combination of different tumour-initiating genetic lesions occurring in different normal stem and progenitor cells in the breast drives breast cancer heterogeneity. We are interested both in inter-tumour heterogeneity – the clinical differences between tumours – as well as intra-tumour heterogeneity and the formation of cells with 'cancer stem cell' properties within a neoplasia. We are also trying to understand how the biological processes occurring in normal stem cells can be re-activated in tumours to drive de novo production of tumour cells with stem cell-like properties.

近期论文

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Jardé, T.et al. 2016. Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids. Nature Communications 7, article number: 13207. (10.1038/ncomms13207) pdf Estrada, M.et al. 2016. Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78, pp. 50-61. (10.1016/j.biomaterials.2015.11.030) pdf Ferrari, N.et al. 2015. Runx2 contributes to the regenerative potential of the mammary epithelium. Scientific Reports 5, article number: 15658. (10.1038/srep15658) pdf Greenow, K. R. and Smalley, M. J. 2015. Overview of genetically engineered mouse models of breast cancer used in translational biology and drug development. Current Protocols in Pharmacology , article number: 70:14.36.1-14.36.14.. (10.1002/0471141755.ph1436s70) Tornillo, G. and Smalley, M. J. 2015. ERrrr...Where are the progenitors? Hormone receptors and mammary cell heterogeneity. Journal of Mammary Gland Biology and Neoplasia 20(1), pp. 63-73. (10.1007/s10911-015-9336-1) pdf Francis, J.et al. 2015. Whole exome DNA sequence analysis of Brca2 and Trp53 deficient mouse mammary gland tumours. Journal of Pathology 236(2), pp. 186-200. (10.1002/path.4517) pdf Iglesias, J.et al. 2015. Annexin A8 identifies a subpopulation of transiently quiescent c-Kit positive luminal progenitor cells of the ductal mammary epithelium. Plos One 10(3), article number: e0119718. (10.1371/journal.pone.0119718) pdf Soady, K.et al. 2015. Mouse mammary stem cells express prognostic markers for triple-negative breast cancer. Breast Cancer Research 17, article number: 31. (10.1186/s13058-015-0539-6) pdf