Shore, Andrew - Cardiff University - School of Biosciences

个人简介

Having completed my undergraduate degree at the Wye Campus of Imperial College London I took up a research assistant post in the Comparative Medicine Section of Imperial which led onto a PhD in the same laboratory. With the continual evolution of research and university departments I left Imperial with a PhD and DIC from the National Heart and Lung Institute within the Faculty of Medicine. This was followed by two years as a lecturing in Dorset on Bournemouth University degrees focussing on comparative anatomy, physiology, nutrition, genetics and epidemiology. While lecturing I completed my PGCertEP, became a Fellow of the Higher Education Academy and gained experience in the delivery of vocational qualifications and promoting widening access to Higher Education. With increasing lecturing commitments my research interests focussed on Bioscience Education, widening access to Higher Education and Bioinformatics. I took up my current post at the School of Biosciences in 2009. Allied to my role as an admissions tutor I have also recently contributed to the Science and Learning Expert Group, developed science units for of level 3, 4 and 5 vocational qualifications (including HNDs) and advised City and Guilds on the progression of vocational learners to Higher Education.

研究领域

Silencing of Uncoupling Protein 1 Expression Uncoupling Protein 1 (UCP1) uncouples the respiratory chain from ATP Synthase by providing an alternative route for protons to cross the inner mitochondrial membrane. When this route is activated large quantities of heat are produced at the expense of ATP. UCP1 is specific to brown adipose tissue. In humans brown adipose tissue is only found in neonates for whom it is vital to maintain their body temperature. Thermogenically active brown adipose tissue consumes more energy than any other tissue, if transcription and activation of this protein could be easily manipulated in adults it may provide an important treatment to combat obesity and the metabolic syndrome. New evidence suggests that DNA methylation and chromatin remodelling may play a key role in regulating UCP1 expression. Although murine models are widely used to study UCP1 expression, epigenetic control of the gene may be significantly different in humans making findings difficult to transfer to humans. Recent research has focussed on identifying and validating more appropriate models for epigenetic regulation of UCP1 transcription in humans. Allied collaborative research projects have included regulation of gene silencing by RIP140 and the role of gene silencing in tumour formation in mouse models for adenoviral gene therapy.

近期论文

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Yhnell, E.et al. 2016. The impact of attaining the Welsh Baccalaureate Advanced Diploma on academic performance in bioscience higher education. International Journal of Science Education 38(1), pp. 156-169. (10.1080/09500693.2015.1135353) pdf Shore, A.et al. 2013. A Comparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue. Frontiers in Genetics 3, article number: 304. (10.3389/fgene.2012.00304) pdf Shore, A.et al. 2013. Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver. PLoS ONE 8(7), article number: e68933. (10.1371/journal.pone.0068933) Shore, A.et al. 2010. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia 53(6), pp. 1164-1173. (10.1007/s00125-010-1701-4) Karamitri, A.et al. 2009. Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1 promoter in white 3T3-L1 and brown HIB-1B preadipocytes. Journal of Biological Chemistry 284(31), pp. 20738-20752. (10.1074/jbc.M109.021766)