Sengpiel, Frank - Cardiff University

个人简介

Diploma in Biology, Ruhr University, Bochum, Germany (1989) DPhil in Physiology, University of Oxford (1994) Junior Research Fellow, Magdalen College, Oxford (1993-1996) Research Fellow, Max-Planck Institute of Neurobiology, Munich (1996-2000)

研究领域

We study the mechanisms of normal development of the primary visual cortex (V1) and the physiological and molecular basis of common developmental disorders of vision such as amblyopia (lazy eye). Specifically, we examine the effects of various rearing regimens on the two principal response characteristics of neurons in V1, binocularity and orientation selectivity. Research over the past 20 years has identified a large number of molecules and pathways that are involved in developmental plasticity as well as in the regulation of the critical period during which the cortex is particularly susceptible to being shaped by sensory experience and indeed requires appropriate experience to develop normally. Glutamate receptors and their downstream signalling pathways play a key role in synaptic plasticity. Gene defects affecting some of the associated postsynaptic proteins have been shown to cause neurodevelopmental disorders (also known as synaptopathies) such as Fragile X. We study developmental plasticity in V1 in models of those disorders using functional brain imaging methods, namely optical imaging of intrinsic signals and two-photon laser scanning microscopy.

近期论文

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Keck, T.et al. 2017. Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 372(1715), article number: 20160158. (10.1098/rstb.2016.0158) pdf Frizzati, A.et al. 2016. Comparable reduction in ZIF268 levels and cytochrome oxidase activity in the retrosplenial cortex following mammillothalamic tract lesions. Neuroscience 330, pp. 39-49. (10.1016/j.neuroscience.2016.05.030) pdf Bobkova, N.et al. 2016. Immunization against specific fragments of neurotrophin p75 receptor protects forebrain cholinergic neurons in the olfactory bulbectomized mice. Journal of Alzheimer's Disease 53(1), pp. 289-301. (10.3233/JAD-160146) pdf Erchova, I.et al. 2016. Enhancement of visual cortex plasticity by dark exposure. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences pdf Vorobyov, V.et al. 2015. Neuroprotective Effects of Hydrated Fullerene C-60: Cortical and Hippocampal EEG Interplay in an Amyloid-Infused Rat Model of Alzheimer's Disease. American Journal of Alzheimers Disease 45(1), pp. 217-233. (10.3233/JAD-142469) Tribble, J.et al. 2014. A novel system for the classification of diseased retinal ganglion cells. Visual Neuroscience 31(6), pp. 373-380. (10.1017/S0952523814000248) pdf Sengpiel, F. 2014. Plasticity of the visual cortex and treatment of amblyopia [Review]. Current Biology 24(18), pp. R936-R940. (10.1016/j.cub.2014.05.063) pdf Hughes, N.et al. 2014. Stripe-rearing changes multiple aspects of the structure of primary visual cortex. NeuroImage 95, pp. 305-319. (10.1016/j.neuroimage.2014.03.031) pdf Ranson, A., Sengpiel, F. and Fox, K. D. 2013. The role of GluA1 in ocular dominance plasticity in the mouse visual cortex. Journal of Neuroscience 33(38), pp. 15220-15225. (10.1523/JNEUROSCI.2078-13.2013) pdf