研究领域
Advances in our understanding of mechanisms of cell death, plasticity and regeneration in the central nervous system offer new opportunities for remediation and repair in several of the most distressing neurodegenerative diseases of adulthood, in particular Parkinson's and Huntington's disease. In the Brain Repair Group, we are seeking to develop new strategies for therapy based on a multidisciplinary approach in several converging problems.
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Precious, S.et al. 2017. Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?. Neurochemistry International (10.1016/j.neuint.2017.01.016) pdf
Lelos, M.et al. 2016. Direct comparison of rat- and human-derived ganglionic eminence tissue grafts on motor function. Cell Transplantation 25, pp. 665-675. (10.3727/096368915X690297) pdf
Drew, C.et al. 2016. Integrating technology into complex intervention trial processes: a case study. Trials 17(1), article number: 551. (10.1186/s13063-016-1674-9) pdf
Straccia, M.et al. 2016. Human t-DARPP is induced during striatal development. Neuroscience 333, pp. 320-330. (10.1016/j.neuroscience.2016.07.022) pdf
Quinn, L.et al. 2016. A randomized, controlled trial of a multi-modal exercise intervention in Huntington's disease. Parkinsonism & Related Disorders 31, pp. 46-52. (10.1016/j.parkreldis.2016.06.023) pdf
Steventon, J.et al. 2016. Longitudinal in vivo MRI in a Huntington's disease mouse model: global atrophy in the absence of white matter microstructural damage. Scientific Reports 6, article number: 32423. (10.1038/srep32423) pdf
Precious, S.et al. 2016. FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation. Experimental Neurology 282, pp. 9-18. (10.1016/j.expneurol.2016.05.002) pdf
Jones, U.et al. 2016. Respiratory decline is integral to disease progression in Huntington's disease [Letter]. European Respiratory Journal 48(2), pp. 585-588. (10.1183/13993003.02215-2015) pdf
Jones, C.et al. 2016. The societal cost of Huntington's disease: are we underestimating the burden?. European Journal of Neurology 23(10), pp. 1588-1590. (10.1111/ene.13107) pdf