Rodrigues, Neil - Cardiff University

个人简介

Dr. Rodrigues has a longstanding interest in stem cell biology, with a particular interest in the haematopoietic system. He initially trained in Professor David Scadden's laboratory at Harvard Medical School and went on to obtain a D.Phil in Clinical Medicine from Green College, University of Oxford under the joint supervision of Professors Scadden, Paresh Vyas and Tariq Enver. Following several years of teaching at Oxford and post-doctoral research training in the Enver laboratory, he established his NIH funded laboratory at Boston University School of Medicine where he also held an Assistant Professor appointment. In September 2013, Dr. Rodrigues was recruited to re-establish his laboratory at the European Cancer Stem Cell Institute. He holds a Readership at Cardiff University.

研究领域

My laboratory is interested in haematopoietic stem/progenitor cell biology and their dysregulation in bone marrow failure and haematologic cancer. We are investigating the transcriptional and post-transcriptional mechanisms regulating haematopoietic stem/progenitor cells, myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) with the ultimate purpose of identifying more specific and less toxic treatment strategies for MDS and AML.

近期论文

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Portero Migueles, R.et al. 2017. Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny. Developmental Biology (10.1016/j.ydbio.2016.12.021) Guitart, A.et al. 2017. Fumarate hydratase is a critical regulator of hematopoietic stem cell functions. Journal of Experimental Medicine pdf Guha, P.et al. 2013. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell 12(4), pp. 407-412. (10.1016/j.stem.2013.01.006) Boyd, A.et al. 2012. Concise review: Immune recognition of induced pluripotent stem cells. Stem Cells 30(5), pp. 797-803. (10.1002/stem.1066) Rodrigues, N.et al. 2012. GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia. The International Journal of Biochemistry & Cell Biology 44(3), pp. 457-460. (10.1016/j.biocel.2011.12.004) Kranc, K.et al. 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5(6), pp. 659-665. (10.1016/j.stem.2009.11.001) Tipping, A.et al. 2009. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood 113(12), pp. 2661-2672. (10.1182/blood-2008-06-161117) Rodrigues, N.et al. 2008. GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood 112(13), pp. 4862-4873. (10.1182/blood-2008-01-136564) Nijnik, A.et al. 2007. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447(7145), pp. 686-690. (10.1038/nature05875) Rodrigues, N.et al. 2005. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood 106(2), pp. 477-484. (10.1182/blood-2004-08-2989) Craiu, A.et al. 2005. Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function. Blood 105(5), pp. 2235-2238. (10.1182/blood-2003-12-4399) Qiu, J.et al. 2004. Regenerative response in ischemic brain restricted by p21cip1/waf1. Journal of Experimental Medicine 199(7), pp. 937-945. (10.1084/jem.20031385)