Riccardi, Daniela - Cardiff University

个人简介

I obtained my BA in Zoology and MRes in Physiopathological methods from the University of Milan, Italy, where I investigated mechanisms of water transport in mammalian epithelia. I did my PhD in Physiology working between the University of Milan and the Harvard Medical School, Boston, USA, under the supervision of Prof. SC Hebert, in the Renal Division of the Brigham and Women's Hospital. Once obtained my PhD, in 1993, I returned to Prof. Hebert lab where I identified and characterised the CaR from mammalian kidney. Following my discoveries on the CaR, I have been awarded the first prize in Excellence in Research from the American Society of Nephrology and National Kidney Foundation, a Research Fellowship from the National Kidney Foundation and The Wellcome Trust Prize for Excellence in Physiology. My current research centres on how cells sense and respond to perturbations in the extracellular milieu, particularly cations (Ca2+), nutrients (amino acids) and, in collaboration with Prof. PJ Kemp, gases (O2, CO and H2S). In 1997, I moved to the UK where I established my own research group at Manchester University and where I remained until 2004. In 2004, I moved to the School of Biosciences at Cardiff University.

研究领域

Molecular mechanisms of cation sensing The ability of cells to sense and respond to changes in the environment is vital to life. Crucial to this process is the extracellular calcium/(cation)-sensing receptor, CaSR. My laboratory is interested in understanding the stimuli serving as signaling molecules at the CaSR in both calciotropic and non-calciotropic tissues in physiology and disease, at the molecular, cellular and whole organism level. Research goals 1. To repurpose CaSR antagonists (calcilytics) as novel therapeutics for inflammatory lung disease; 2. To define the role of the CaSR in blood pressure control and in the prevention of vascular calcification; 3. To determine the role of the CaSR in human fetal lung development; 4. To develop an in vitro human primary kidney cell model for studies of drug-induced kidney injury and mineral ion metabolism.

近期论文

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Musante, I.et al. 2017. Phenotypic characterization of Grm1crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization. Bone 94, pp. 114-123. (10.1016/j.bone.2016.10.025) pdf Kemp, P.et al. 2016. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 594(22), pp. 6583-6594. (10.1113/JP270655) pdf Riccardi, D. and Valenti, G. 2016. Localization and function of the renal calcium-sensing receptor. Nature Reviews Nephrology 12(7), pp. 414-425. (10.1038/nrneph.2016.59) Graca, J.et al. 2016. Comparative expression of the extracellular calcium sensing receptor in rat, mouse and human kidney. American Journal of Physiology-Renal Physiology 310(6), article number: F518-F533. (10.1152/ajprenal.00208.2015) pdf Brennan, S.et al. 2016. The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR. Scientific Reports 6, article number: 21975. (10.1038/srep21975) pdf Schepelmann, M.et al. 2016. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. American Journal of Physiology - Cell Physiology 310(3), pp. C193-C204., article number: ajpcell.00248.2015. (10.1152/ajpcell.00248.2015) pdf Mattinzoli, D.et al. 2016. FGF23-regulated production of Fetuin-A (AHSG) in osteocytes. Bone 83, pp. 35-47. (10.1016/j.bone.2015.10.008) pdf Riccardi, D. and Valenti, G. 2016. The calcium-sensing receptor in the kidney: localisation, function and therapeutic implications. Nature Reviews Nephrology pdf Lopez-Fernandez, I.et al. 2015. The calcium-sensing receptor: one of a kind. Experimental Physiology 100(12), pp. 1392-1399. (10.1113/EP085137) pdf Yarova, P.et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282) pdf Vazquez, M.et al. 2014. A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Frontiers in Endocrinology 5, article number: 208. (10.3389/fendo.2014.00208) pdf