Ramji, Dipak - Cardiff University - School of Biosciences

个人简介

I did my BSc in Biochemistry and PhD on Dictyostelium development at The University of Leeds. This was followed by postdoctoral research at the European Molecular Biology Laboratories (Heidelberg) and Istituto di Ricerche di Biologia Molecolare "P. Angeletti" (Rome) on the molecular mechanisms underlying liver-specific gene expression during inflammation. I was a recipient of fellowships from the Royal Society, EMBL, University of Rome and the EU. I moved to Cardiff University as a Lecturer in August 1992. I was promoted to a Senior Lecturer in 2003 and to a Reader in 2006.

研究领域

Research interests focus on understanding the molecular mechanisms underlying the changes in key cellular processes during inflammatory disorders with the goal of identifying new therapeutic/preventative targets/avenues. Research employs a combination of cell culture and mouse model systems coupled with molecular, biochemical, immunological and pharmacological approaches. Specific focus is on understanding how key factors associated with inflammatory disorders, such as cytokines and lipid metabolites, regulate macrophage processes and gene expression during atherosclerosis and the acute-phase response. In particular, we are elucidating the pathways leading from the interaction of such factors with their receptors, through the signalling cascades, to the control of gene expression in the nucleus and the subsequent regulation of cellular processes. More recently, the mechanisms underlying the protective actions of nutraceuticals in atherosclerosis and key cellular processes associated with this disease are being investigated. Previous and current research has been funded by grants from the British Heart Foundation, Wellcome Trust, BBSRC, MRC, EU and Industry.

近期论文

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Salter, R.et al. 2016. The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake. Scientific Reports 6, article number: 34368. (10.1038/srep34368) pdf Moss, J. W. E. and Ramji, D. P. 2016. Nutraceutical therapies for atherosclerosis. Nature Reviews Cardiology 13(9), pp. 513-532. (10.1038/nrcardio.2016.103) pdf Moss, J. and Ramji, D. P. 2016. Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets. Future Medicinal Chemistry 8(11), pp. 1317-1330. (10.4155/fmc-2016-0072) Michael, D.et al. 2016. Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes. Beneficial Microbes 7(3), pp. 443-451. (10.3920/BM2015.0146) pdf Moss, J.et al. 2016. A unique combination of nutritionally active ingredients can prevent several key processes associated with atherosclerosis in vitro. PLoS ONE 11(3), article number: e0151057. (10.1371/journal.pone.0151057) pdf Huwait, E.et al. 2015. Protein Kinase C is involved in the induction of ATP-Binding cassette transporter A1 expression by liver X receptor/retinoid X receptor agonist in human macrophages. Journal of Cellular Biochemistry 116(9), pp. 2032-2038. (10.1002/jcb.25157) Moss, J. and Ramji, D. P. 2015. Interferon-γ: Promising therapeutic target in atherosclerosis. World Journal of Experimental Medicine 5(3), pp. 154-159. (10.5493/wjem.v5.i3.154) pdf Buckley, M. and Ramji, D. P. 2015. The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1852(7), pp. 1498-1510. (10.1016/j.bbadis.2015.04.011) pdf