Mason, Deborah - Cardiff University - School of Biosciences

个人简介

After my BSc in Zoology and Genetics (1986) and my PhD in Evolutionary Genetics (1991) in Cardiff, I worked briefly in Medical Genetics at the University Hospital of Wales before moving to Bristol University. My research in Bristol revealed osteocyte gene expression in vivo and implicated glutamatergic signalling in mechanically-induced bone formation. Since my appointment as Lecturer in Cardiff University in 1996 (Senior Lecturer in 2009, Reader in 2012), I have investigated the role of glutamate transporters in bone, revealed a pathological role for glutamate in arthritis, and identified new pathways of cytokine- and mechanically- induced cartilage degradation involving PKR, ceramide and the cytoskeleton. I have secured over £12M of research funding for 30 projects. I co-ordinated Cardiff's bid for the Arthritis Research UK-funded Centre of Excellence in Biomechanics and Bioengineering, where I act as a manager, and as the Biomechanics, Inflammation and Pain Team Leader. I have served on the Bone Research Society and the British Orthopaedic Research Committees. I have supervised 11 PhD/MD students and teach undergraduate students, co-ordinating the Molecular Biology Degree Scheme in Cardiff and acting as final year tutor for all Biomolecular Degree Schemes. I regularly contribute to public engagement activities with school children, patients and fundraisers.

研究领域

My research elucidates new signalling mechanisms that regulate bone and cartilage turnover, to provide therapeutic and diagnostic targets for osteoporosis, rheumatoid arthritis and osteoarthritis. This has led to the discovery of functional glutamatergic signalling in bone and synovium, and revealed new pathways that mediate cytokine- and mechanically- induced cartilage degradation. Modulation of glutamatergic signalling to enhance bone formation and inhibit pathological changes in arthritis, and delineating the role of PKR in arthritis, are current research priorities.

近期论文

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Holt, C.et al. 2016. Biological changes in tibial subchondral bone following high tibial osteotomy. Osteoarthritis and Cartilage 24(S1), pp. S511-S511. (10.1016/j.joca.2016.01.935) Felson, D.et al. 2015. Recommendations for the conduct of efficacy trials of treatment devices for osteoarthritis: a report from a working group of the Arthritis Research UK Osteoarthritis and Crystal Diseases Clinical Studies Group: Box 1. Rhuematology 55(2), pp. 320-326. (10.1093/rheumatology/kev328) Eastwood, S.et al. 2015. Osteoclastogenesis-related cytokines and peri-prosthetic osteolysis in revision metal-on-metal total hip replacements. Hip International 25(4), pp. 355-360. (10.5301/hipint.5000241) Vazquez, M.et al. 2014. A new method to investigate how mechanical loading of osteocytes controls osteoblasts. Frontiers in Endocrinology 5, article number: 208. (10.3389/fendo.2014.00208) pdf Gilbert, S.et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174) pdf Sanders, R.et al. 2014. Considerations for accurate gene expression measurement by reverse transcription quantitative PCR when analysing clinical samples. Analytical and Bioanalytical Chemistry 406(26), pp. 6471-6483. (10.1007/s00216-014-7857-x) Gilbert, S.et al. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078) Bonnet, C.et al. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95(3), pp. A5-A6. Scully, N.et al. 2014. Development of a novel 3D mineralising culture system to investigate the differentiation of osteoblasts to osteocytes. International Journal of Experimental Pathology 95(3), pp. A29-A29. (10.1111/iep.12078) Vazquez, M.et al. 2014. Development of a novel in vitro 3D osteoblast-osteocyte co-culture model to investigate mechanically-induced signalling. International Journal of Experimental Pathology 95(3), pp. A34-A35. Bonnet, C.et al. 2013. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74, pp. 242-251. (10.1136/annrheumdis-2013-203670) pdf Sanders, R.et al. 2013. Evaluation of digital PCR for absolute RNA quantification. PLoS ONE 8(9), article number: e75296. (10.1371/journal.pone.0075296) pdf