Martinez Garay, Isabel - Cardiff University

研究领域

We are interested in the roles that adhesion proteins of the cadherin superfamily, in particular the delta-protocadherins, play during development of the cerebral cortex. Our primary approach involves mouse molecular genetics, complemented by cell biological studies to gain insight into the functions of these adhesion molecules and the mechanisms by which they work. We aim to understand the cell biology of neurons during normal development, but also in pathological conditions that give rise to neurological disorders.

近期论文

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Martinez Garay, I.et al. 2016. Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice. Brain Structure and Function (10.1007/s00429-016-1282-1) pdf Martinez Garay, I.et al. 2016. Cadherin2/4-signaling via PTP1B and catenins is critical for nucleokinesis during radial neuronal migration in the neocortex. Development 143, pp. 2121-2134. (10.1242/dev.132456) pdf Gil-Sanz, C.et al. 2015. Lineage tracing using cux2-Cre and cux2-creERT2 mice. Neuron 86(4), pp. 1091-1099. (10.1016/j.neuron.2015.04.019) Gil-Sanz, C.et al. 2013. Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues. Neuron 79(3), pp. 461-477. (10.1016/j.neuron.2013.06.040) Franco, S.et al. 2012. Fate-restricted neural progenitors in the mammalian cerebral cortex. Science 337(6095), pp. 746-749. (10.1126/science.1223616) Franco, S.et al. 2011. Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron 69(3), pp. 482-497. (10.1016/j.neuron.2011.01.003) Gil-Sanz, C. and Martinez Garay, I. 2010. VISIONS: the art of science. Molecular Reproduction and Development 77(3), pp. 195. (10.1002/mrd.21159) Llorens, J.et al. 2008. Gypsy endogenous retrovirus maintains potential infectivity in several species of Drosophilids. BMC Evolutionary Biology 8(1), article number: 302. (10.1186/1471-2148-8-302) pdf Rosello, M.et al. 2007. Subtelomeric deletion 9qter: definition of the syndrome and parental origin in 2 patients. Medical Clinics 128(11), pp. 419-421.