个人简介

Ph.D. University of Florida, 1999

研究领域

Physical

Biophysical Electron Paramagnetic Resonance in Structural Biology Our lab utilizes site-directed spin labeling and magnetic resonance (EPR and NMR) biophysical approaches to answer questions relevant in cell biology and microbiology. These topics include (a) the association/binding of peptides/proteins with biological membrane surfaces, (b) membrane biophysics (c) membrane protein structure, dynamics, conformational changes, (d) conformational changes in HIV-1 protease (e) "structure" and dynamics of natively unfolded peptides and proteins.

近期论文

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T.E. Frederick, J.N. Chebukati, C.E. Mair, P.C. Goff and G.E. Fanucci, "Bis(monoacylglycero)phosphate Forms Stable Small Lamellar Vesicle Structures: Insights into Vesicular Body Formation in Endosomes" Biophys. J., accepted, 2009. L. Galiano, M.E. Blackburn, A.M. Veloro, M. Bonora, and G.E. Fanucci, "Solute Effects on Spin Labels at an Aqueous Exposed Site in the Flap Region of HIV-1 Protease" J. Phys. Chem. B, ASAP 2009. L. Galiano, D. Fengu, A.M. Veloro, M.E. Blackburn, C. Simmerling and G.E. Fanucci, "Drug Pressure Induced Mutations in HIV-1 Protease alter Flap Conformations" J. Am. Chem. Soc. ASAP 2008. Y. Ran and G.E. Fanucci "A Dansyl-Fluorescence Based Assay for Monitoring Kinetics of Lipid Extraction and Transfer" Notes and Tips Communication, Anal. Biochem. ,382(2), 132-4, 2008. L. Galiano, M. Bonora, G. E. Fanucci "Interflap Distances in HIV-1 Protease Determined by Pulsed EPR Measurements" J. Am. Chem. Soc., 129, 11004-5 2007. V. Lukova, M. Peng, G. E. Fanucci, R. Tandlich, A. Hinderliter, B. Maity, E.Manivannan, G. R. Cook, S. Balaz. "Drug-Membrane Interactions Studied in Phospholipid Monolayers Adsorbed on Non-Porous Aklylated Microspheres" J. Biomolecular Screening, 12, 186-202, 2007. M. Kim, G.E. Fanucci and D.S. Cafiso "Substrate-Dependent Signaling in TonB-Dependent Transporters Investigated Using Site-Directed Spin Labeling" Proc. Nat. Acad. Sci.,104, 11975-80, 2007. G. E. Fanucci and D. S. Cafiso "Recent Advances and Applications in Site-Directed Spin Labeling" Curr Opin Struc Bio, 16, 644-53, 2006. M. Kim, Q. Xu, G. E. Fanucci, D. S. Cafiso "Solutes Modify a Conformational Transition in a Membrane Transport Protein" Biophysical Journal, 90, 2922-9, 2006. G. E. Fanucci, J. Y. Lee, D. S. Cafiso "Membrane Mimetic Environments Alter the Conformation of the Outer Membrane Protein BtuB" J. Am. Chem. Soc., 125, 13932-13933, 2003. G. E. Fanucci, J. Y. Lee, D. S. Cafiso "Spectroscopic Evidence that Osmolytes Used in Crystallization Buffers Inhibit a Conformational Change in a Membrane Protein" Biochemistry, 42, 13106-13112, 2003. G. E. Fanucci, N. Cadieux, R. J. Kadner, D. S. Cafiso "Competing Ligands Stabilize Alternate Conformations of the Energy Coupling Motif of a TonB-Dependent Outer Membrane Transporter" Proc. Nat. Acad. Sci., 100, 11382-11387, 2003. G. E. Fanucci, K. A. Coggshall, N. Cadieux, M Kim, R. J. Kander, D. S. Cafiso "Substrate-Induced Conformational Changes of the Periplasmic N-terminus of an Outer-Membrane Transporter by Site-Directed Spin Labeling" Biochemistry, 42, 1391-1400, 2003. G. E. Fanucci, N. Cadieux, C. A. Piedmont, R. J. Kander, D. S. Cafiso "Structure and Dynamics of the b-barrel of the Membrane Transporter, BtuB by Site-Directed Spin Labeling" Biochemistry, 41, 11543-11551, 2002. A. A. Frazier, M. A. Wisner, N. J. Malmberg, K. G. Victor, G. E. Fanucci, E. A. Nalefski, J. J. Falke, D. S. Cafiso. "Membrane Orientation and Position of the C2 Domain from cPLA2 by Site-Directed Spin Labeling" Biochemistry, 41, 6282-6292, 2002. G. E. Fanucci, R. Backov, R. Fu, D. R. Talham "Multiple Bilayer Dipalmitoylphosphatidylserine (DPPS) LB Films Stabilized with Transition Metal Ions." Langmuir, 17, 1660, 2001.