Lloyd-Evans, Emyr - Cardiff University

个人简介

My first degree was an undergraduate masters in Biochemistry (M.Biochem) at the University of Bath. During this degree I spent 11 months (2 successive placements) in the lab of Prof. Tony Futerman at the Weizmann Institute of Science, Rehovot, Israel. It was here that I gained an interest in lysosomal storage diseases, researching the role of altered endoplasmic reticulum Ca2+ homeostasis in Gaucher disease. Following my degree in 2002 I moved to Oxford to do my DPhil with Prof. Fran Platt at the Glycobiology Institute. Here I researched the role of the simple sphingolipid sphingosine in the pathogenesis of Niemann-Pick type C1. Upon completion of my DPhil In 2005, I moved with Fran to the Department of Pharmacology (Oxford) where, in collaboration with Prof. Antony Galione, we developed techniques to study lysosomal Ca2+ homeostasis in the lysosomal diseases. In 2010 I was appointed as an RCUK Fellow at the School of Biosciences, Cardiff University, to continue my research into lysosomal function.

研究领域

Lysosomes are a subset of organelles that are crucial for cellular function, as epitomised by the 50 human diseases that are caused by mutations in the genes encoding lysosomal and associated proteins. My laboratory is interested in the function of novel uncharacterised lysosomal transmembrane proteins, their roles in normal cellular function and the events that unfold when these proteins become dysfunctional in lysosomal diseases. We are particularly interested in applying our research on lysosomal proteins to other human diseases, particularly infectious and neurodegenerative diseases. Lysosomal research is an emerging area owing to the development of new tools capable of measuring lysosomal function at the acidic pH found within these compartments. My lab utilises these tools to investigate the function of this enigmatic class of organelles.

近期论文

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Lloyd-Evans, E. and Haslett, L. 2016. The lysosomal storage disease continuum with ageing-related neurodegenerative disease. Ageing Research Reviews 32, pp. 104-121. (10.1016/j.arr.2016.07.005) Lloyd-Evans, E. 2016. On the move, lysosomal CAX drives Ca2+ transport and motility. Journal of cell biology 212(7), pp. 755-757. (10.1083/jcb.201603037) pdf Oswald, M.et al. 2015. Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1. Human Molecular Genetics 24(24), pp. 6899-6909. (10.1093/hmg/ddv390) pdf Lee, J.et al. 2015. Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Reports 12(9), pp. 1430-1444. (10.1016/j.celrep.2015.07.050) Chandrachud, U.et al. 2015. Unbiased cell-based screening in a neuronal cell model of Batten Disease highlights an interaction between Ca2+Homeostasis, autophagy, and CLN3 protein function. Journal of Biological Chemistry 290(23), pp. 14361-14380.. (10.1074/jbc.M114.621706) Waller-Evans, H. and Lloyd-Evans, E. 2015. Regulation of TRPML1 function. Biochemical Society Transactions 43(3), pp. 442-446. (10.1042/BST20140311) Platt, F.et al. 2014. Disorders of cholesterol metabolism and their unanticipated convergent mechanisms of disease. Annual Review of Genomics and Human Genetics 15(1), pp. 173-194. (10.1146/annurev-genom-091212-153412) Morgan, A.et al. 2011. Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease. Biochemical Journal 439(3), pp. 349-374. (10.1042/BJ20110949) Lloyd-Evans, E. and Platt, F. M. 2011. Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases. Cell Calcium 50(2), pp. 200-205. (10.1016/j.ceca.2011.03.010) Lloyd-Evans, E.et al. 2010. Endolysosomal calcium regulation and disease.. Biochemical Society Transactions 38(6), pp. 1458-1464. (10.1042/BST0381458)