Latinkic, Branko V. - Cardiff University

个人简介

1987. BSc in molecular biology, Belgrade University. 1994. PhD in molecular genetics, University of Illinois at Chicago. Regulation of mammalian immediate-early genes, the lab of Prof. Lester Lau. 1995-1998. Postdoc with Dr. Jim Smith, National Institute for Medical Research, Mill Hill. Mechanisms of mesoderm induction. 1999-2003. Postdoc with Dr. Tim Mohun, National Institute for Medical Research, Mill Hill. Mechanisms of cardiac induction and gene expression. 2004- Lecturer in School of Biosciences, Cardiff University.

研究领域

My group studies the molecular and cellular mechanisms of early heart development in vertebrates. Our focus is on the first step in heart development, cardiac specification by inductive signals from the anterior endoderm in embryos of two frog species, Xenopus leavis and Xenopus tropicalis.

近期论文

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Caporilli, S. and Latinkic, B. 2016. Ventricular cell fate can be specified until the onset of myocardial differentiation. Mechanisms of Development 139, pp. 31-41. (10.1016/j.mod.2016.01.001) pdf Freeman, J.et al. 2015. A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators. Molecular Cancer 14(1), article number: 206. (10.1186/s12943-015-0475-1) pdf Gallagher, J.et al. 2014. Carboxy terminus of GATA4 transcription factor is required for its cardiogenic activity and interaction with CDK4. Mechanisms of Development 134, pp. 31-41. (10.1016/j.mod.2014.09.001) pdf Yamak, A.et al. 2014. Cyclin D2 is a GATA4 cofactor in cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America 111(4), pp. 1415-1420. (10.1073/pnas.1312993111) pdf Gallagher, J.et al. 2012. Dissociation of cardiogenic and postnatal myocardial activities of GATA4. Molecular and Cellular Biology 32(12), pp. 2214-2223. (10.1128/MCB.00218-12) pdf Ewan, K.et al. 2010. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Research 70(14), pp. 5963-5973. (10.1158/0008-5472.CAN-10-1028) Samuel, L. and Latinkic, B. 2009. Early activation of FGF and Nodal pathways mediates cardiac specification independently of Wnt/β-catenin signaling. PLoS ONE 4(10), article number: e7650. (10.1371/journal.pone.0007650) pdf Walters, Z. S., Haworth, K. and Latinkic, B. 2009. NKCC1 (SLC12a2) induces a secondary axis in Xenopus laevis embryos independently of its co-transporter function. Journal of Physiology 587(3), pp. 521-529. (10.1113/jphysiol.2008.161562) Haworth, K. E. and Latinkic, B. 2009. Expression of Xenopus tropicalis HNF6/Onecut-1. International Journal of Developmental Biology 53(1), pp. 159-162. (10.1387/ijdb.072472ke) Haworth, K.et al. 2008. GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos. BMC Developmental Biology 8, article number: 74. (10.1186/1471-213X-8-74) pdf Smith, S.et al. 2006. Xenopus laevis transgenesis by sperm nuclear injection. Nature Protocols 1(5), pp. 2195-2203. (10.1038/nprot.2006.325)