Hughes, Clare - Cardiff University - School of Biosciences

研究领域

Research interests include: The mechanisms by which ADAMTS-4 & TS-5 ('the aggrecanases' ) are involved in cartilage destruction during the pathogenesis of osteoarthritis. Part of this work has led to the novel discovery of an alternative splice-variant of ADAMTS-4 synthesised in synovial tissue. The mechanisms by which glycosaminoglycan sulphation motifs influence the differentiation of mesenchymal stem cells to connective tissue lineages with a particular focus on chondrogenesis. The pathogenesis of Kashin Beck Disease an endemic osteoarthropathy in China.

近期论文

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Hayes, A.et al. 2016. The CS sulphation motifs 4C3, 7D4, 3B3[-]; and perlecan identify stem cell populations and niches, activated progenitor cells and transitional tissue development in the fetal human elbow. Stem Cells and Development 25(11), pp. 836-847. (10.1089/scd.2016.0054) pdf Bascoul-Colombo, C.et al. 2015. Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1 in bovine cartilage explants. Cartilage 7(1), pp. 70-81. (10.1177/1947603515603762) pdf Esa, A.et al. 2015. Investigating the role of Wnt antagonist protein Dkk-1 in the pathogenesis of osteoarthritis. International Journal of Experimental Pathology 96(2), pp. A29-A29. Chen, J.et al. 2015. Altered proteolytic activity and expression of mmps and aggrecanases and their inhibitors in Kashin-Beck disease. Journal of Orthopaedic Research 33(1), pp. 47-55. (10.1002/jor.22708) Luo, M.et al. 2014. Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease. Osteoarthritis and Cartilage 22(7), pp. 986-995. (10.1016/j.joca.2014.05.012) Wainwright, S.et al. 2013. ADAMTS4_v1 is a splice variant of ADAMTS4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain. Arthritis & Rheumatism 65(11), pp. 2866-2875. (10.1002/art.38102) pdf Shu, C.et al. 2013. The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal 30(7), pp. 717-725. (10.1007/s10719-013-9475-9) Guan, F.et al. 2013. Histopathology of chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and selenium deficiency conditions. Rheumatology International 33(1), pp. 157-166. (10.1007/s00296-011-2335-7)