Harwood, John - Cardiff University - School of Biosciences

研究领域

Past and current research in my laboratory is focussed on the metabolism and function of acyl lipids. This work has involved elucidating new metabolic pathways, isolating and studying important enzymes and delineating regulatory mechanisms. For the latter, we have pioneered the application of flux control analysis to lipid biosynthesis. Research is concentrated in three main areas. First, we have studied the effect of environmental stresses on lipid metabolism. Second, we have examined the biosynthesis of different plant lipids and regulatory mechanisms. This work has included both membrane and storage lipids and their constituent fatty acids. A third area concerns medical complaints where lipids play a key role. Arthritis, cardiovascular disease and dementia are the three main foci.

近期论文

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Woodfield, H.et al. 2017. Spatial and temporal mapping of key lipid species in Brassica napus seeds. Plant Physiology , article number: 01705. (10.1104/pp.16.01705) pdf Stokes, C.et al. 2016. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology 9(5), pp. 1303-1316. (10.1038/mi.2015.137) pdf Bascoul-Colombo, C.et al. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861, pp. 524-537. (10.1016/j.bbalip.2016.03.005) pdf Wacker, A.et al. 2016. Light-induced changes in fatty acid profiles of specific lipid classes in several freshwater phytoplankton species. Frontiers in Plant Science 7, article number: 264. (10.3389/fpls.2016.00264) pdf Hall, J.et al. 2016. Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory 130, pp. 118-128. (10.1016/j.nlm.2016.02.002) pdf Nicolaou, A. and Harwood, J. L. 2016. Skin lipids in health and disease. Lipid Technology 28(2), pp. 36-39. (10.1002/lite.201600012) Chen, G.et al. 2015. Acyl-trafficking during plant oil accumulation. Lipids 50(11), pp. 1057-1068. (10.1007/s11745-015-4069-x) Bascoul-Colombo, C.et al. 2015. Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1 in bovine cartilage explants. Cartilage 7(1), pp. 70-81. (10.1177/1947603515603762) pdf Escribá, P.et al. 2015. Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Progress in Lipid Research 59, pp. 38-53. (10.1016/j.plipres.2015.04.003) Woodfield, H., Harwood, J. L. and Weselake, R. J. 2015. Tailoring lipid synthesis in oil crops. Inform 26(2), pp. 78-83.