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个人简介

Following my BA in Zoology from the University of Oxford, I investigated gene targeting by mitotic homologous recombination in cultured mammalian cells at the University of Edinburgh under the supervision of Chris Bostock, being awarded a PhD in 1988. My further research has focused on the study of signal transduction processes in the context of cell biology. Initially, I held a Research Fellowships at the ICRF Clare Hall Laboratories (1988-1991) in the group of Jeff Williams. During this period, I pioneered the study of cAMP-dependent protein kinase inDictyostelium, establishing the basic role of this important kinase in spatial and temporal control during development. I also established a number of key technologies for Dictyostelium research, including the use of lacZ marker genes. I was awarded a MRC Post-doctoral Fellowship at the MRC Laboratory of Molecular Biology, Cambridge, (1992-1994) in the group of Rob Kay. Here, I carried out the first REMI mutagenesis screens outside the US, leading to discovering the essential role of GSK-3 in cell and developmental biology of Dictyostelium. In 1995 I was awarded a Wellcome Trust Senior Biomedical Fellowship and established my own research group at the MRC Laboratory for Molecular Cell Biology (LMCB), holding a staff position in the Dept of Biology at University College London. I was promoted to Reader in 2001 and a personal chair in 2003. During this period, I continued to study GSK-3 signalling in Dictyostelium and developed an international reputation in the area of Wnt signaling. I discovered the first beta-catenin and the existence of adherens junctions outside the metazoa, published in Nature. In addition, my Cell paper on GSK-3 was a cornerstone for the discovery that lithium inhibits GSK-3. I have continued to investigate the role of lithium on cellular signaling pathways, investigating both GSK-3 and inositol phosphate signaling in both Dictyostelium and neurons. My 2002 Nature paper is a seminal paper in the field of psychopharmacology, showing that inositol phosphate signaling is a common target of the majority of mood stabilizers. In 2005, I moved to the School of Biosciences at Cardiff University, and was a co-founder of the University's Neuroscience and Mental Health Research Institute (NMHRI). I have continued to develop my research into the neurocellular basis of psychiatric disorders and the mechanism of action of mood stabilizers. I am a regular speaker at the BAP, CINP and ACNP, and a member of the CINP and Fellow of the Society of Biology (FSB).

研究领域

I am cell biologist based in the Neuroscience and Mental Health Research Institute (NMHRI), and School of Biosciences. I have extensive experience in molecular signalling systems and cell analysis in neuronal and model cell systems. My current work focuses on the molecular and cellular interactions that underlie genetic risk for psychiatric conditions and epilepsy. Current projects focus on cell signalling, cytoskeletal regulation and motility and epigenetic mechanisms that modulate cell behaviour and drug sensitivity. We are using human stem cells to create new model systems for the study of neuropsychiatric disorders and pharmacological analysis. This work aims to both develop new therapeutic strategies and provide basic insight into the cellular mechanisms underlying mental illnesses. As a world leader in the emerging field of cellular psychopharmacology, I am also studying the interaction of psychotropic drugs in the cellular context. I investigate phospho-inositide signalling and the protein kinase GSK-3 function, the two major lithium targets, recently discovering that lithium suppresses PIP3 signalling.

近期论文

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Falk, A.et al. 2016. Modeling psychiatric disorders: from genomic findings to cellular phenotypes. Molecular Psychiatry 21(9), pp. 1167-1179. (10.1038/mp.2016.89) pdf Tarrés, M.et al. 2015. Biological interaction of living cells with COSAN-based synthetic vesicles. Scientific Reports 5, article number: 7804. (10.1038/srep07804) pdf Tarrés, M.et al. 2014. Imaging in living cells using νB–H Raman spectroscopy: monitoring COSAN uptake. Chemical Communications 50(25), pp. 3370-3372. (10.1039/c3cc49658a) pdf Platt, J.et al. 2013. Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum. Development 140(24), pp. 4926-4936. (10.1242/dev.099879) pdf Platt, J.et al. 2013. Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum. Development 140(24), pp. 4926-4936. (10.1242/dev.099879) pdf Harwood, A.et al. 2013. Aberrant spindle dynamics and cytokinesis in Dictyostelium discoideum cells that lack glycogen synthase kinase 3. European Journal of Cell Biology 92(6-7), pp. 222-228. (10.1016/j.ejcb.2013.05.001) pdf Fox, M.et al. 2013. Phosphorylation of the Actin Binding Protein Drebrin at S647 Is Regulated by Neuronal Activity and PTEN. PLoS ONE 8(8), article number: e71957. (10.1371/journal.pone.0071957) Harwood, A. J. 2011. Prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity. CNS & Neurological Disorders - Drug Targets 10(3), pp. 333-339. (10.2174/187152711794653779) Perrins, R.et al. 2011. Doing more with less: a method for low total mass, affinity measurement using variable-length nanotethers. Analytical Chemistry 83(23), pp. 8900-8905. (10.1021/ac2012569) Teo, R.et al. 2010. Glycogen synthase kinase-3 is required for efficient 'Dictyostelium' chemotaxis. Molecular Biology of the Cell 21(15), pp. 2788-2796. (10.1091/mbc.E09-10-0891) pdf

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