Duance, Victor - Cardiff University - School of Biosciences

研究领域

Arthritis Research UK in 2009 selected Cardiff University to become its prestigious UK Centre of Excellence in Biomechanics and Bioengineering. The Centre is driving interdisciplinary studies across a team of internationally recognised researchers and clinicians to improve patient care. The team applies a 'molecule to man' approach to investigate normal joint biomechanics and determine how this is influenced by pathology to inform clinical intervention and rehabilitation in musculoskeletal disorders. There are three main themes to the work of my research group (i) the structure and function of the minor collagens of cartilage, in particular types III, IX, X and XI, how they change with age and in disease, as well as their importance in cartilage repair (ii) elucidation of the cell signalling pathways associated with mechanical and cytokine mediated cartilage degeneration and (iii) strategies for enhancing cartilage repair.

近期论文

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Al-Sabah, A.et al. 2016. Importance of reference gene selection for articular cartilage mechanobiology studies. Osteoarthritis and Cartilage 24(4), pp. 719-730. (10.1016/j.joca.2015.11.007) pdf Fu, Q.et al. 2015. Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study. Osteoarthritis and Cartilage 23(6), pp. 868-873. (10.1016/j.joca.2015.01.009) Chen, J.et al. 2015. Altered proteolytic activity and expression of mmps and aggrecanases and their inhibitors in Kashin-Beck disease. Journal of Orthopaedic Research 33(1), pp. 47-55. (10.1002/jor.22708) Gilbert, S.et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174) pdf Li, S.et al. 2014. Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS ONE 9(10), article number: e109536. (10.1371/journal.pone.0109536) pdf Gilbert, S.et al. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078) Blain, E. J., Thomas, R. S. and Duance, V. C. 2012. Effect of Wnt3A on load-induced markers of chondrocyte matrix metabolism. International Journal of Experimental Pathology 93(4), pp. A13-A14. (10.1111/j.1365-2613.2012.00822.x) Gilbert, S.et al. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57. Parsons, P.et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188) Li, S.et al. 2011. The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study. European Cells and Materials 21, pp. 508-522. Thomas, R.et al. 2011. Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Research and Therapy 13(6), article number: R203. (10.1186/ar3536) pdf