Davies, Alun - Cardiff University - School of Biosciences

个人简介

I did degrees in biochemistry and medicine at Liverpool University followed by a PhD in developmental neurobiology at London University. I have held appointments as Lecturer, Senior Lecturer and Reader in Neurobiology in London University, Professor of Developmental Neurobiology at St. Andrews University School of Biology, Professor of Physiology at Edinburgh University Veterinary School and Executive Vice President of Research at Rinat Neuroscience Corp., USA. I was elected Fellow of the Royal Society of Edinburgh in 2000, Member of the European Molecular Biology Organisation in 2000, Fellow of the Academy of Medical Sciences in 2010, Fellow of the Learned Society of Wales in 2011, Member of the Academia Europaea in 2011 and Fellow of the Royal Society in 2011. I was appointed Distinguished Research Professor in Cardiff University in 2004 and became a Wellcome Trust Senior Investigator in 2014.

研究领域

We use a wide variety of cellular, molecular and transgenic approaches to understand the regulation of neuronal survival and the growth of neural processes in the developing vertebrate nervous system, focusing on the functions and mechanisms of action of neurotrophic factors and members of the TNF superfamily. We mostly work on experimentally advantageous populations of neurons in the peripheral nervous system, but have begun to apply our multi-disciplinary approach to study dendritic development in the central nervous system.

近期论文

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O'Keeffe, G.et al. 2016. Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation. Neural Development 11, article number: 4. (10.1186/s13064-016-0060-3) pdf Vizard, T.et al. 2015. ERK signaling mediates CaSR-promoted axon growth. Neuroscience Letters 603, pp. 77-83. (10.1016/j.neulet.2015.07.019) pdf McWilliams, T.et al. 2015. Regulation of autocrine signaling in subsets of sympathetic neurons has regional effects on tissue innervation. Cell Reports 10(9), pp. 1443-1449. (10.1016/j.celrep.2015.02.016) pdf Osório, C.et al. 2014. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Molecular and Cellular Neuroscience 59, pp. 24-36. (10.1016/j.mcn.2014.01.002) pdf Osorio, C.et al. 2013. Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. Development 140(23), pp. 4751-4762. (10.1242/dev.101378) pdf Kisiswa, L.et al. 2013. TNFα reverse signaling promotes sympathetic axon growth and target innervation. Nature Neuroscience 16(7), pp. 865-873. (10.1038/nn.3430) Howard, L.et al. 2013. ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75(NTR)-dependent mechanism. Development 140(10), pp. 2108-2117. (10.1242/dev.085266) pdf Gatto, G.et al. 2013. Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling. Journal of Neuroscience 33(12), pp. 5399-5410. (10.1523/JNEUROSCI.4707-12.2013) pdf Gutierrez, H.et al. 2013. Regulation of neurite growth by tumour necrosis superfamily member RANKL. Open Biology 3(1), article number: 120150. (10.1098/rsob.120150) pdf Gutierrez, H. and Davies, A. M. 2011. Regulation of neural process growth, elaboration and structural plasticity by NF-κB. Trends in Neurosciences 34(6), pp. 316-325. (10.1016/j.tins.2011.03.001)