Carter, David - Cardiff University - School of Biosciences

研究领域

My laboratory focuses on molecular neuroscience. We study the nuclear mechanisms in neurons that pattern gene expression according to temporal changes in functional requirements. We produce transgenic rat models that allow us to conduct long-term studies of specific genomic sequences and transcriptional regulators in a physiological context.

近期论文

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Hoefflin, S. and Carter, D. A. 2014. Neuronal expression of SOX2 is enriched in specific hypothalamic cell groups. Journal of Chemical Neuroanatomy 61-62, pp. 153-160. (10.1016/j.jchemneu.2014.09.003) pdf Man, P., Wells, T. and Carter, D. A. 2014. Cellular distribution of Egr1 transcription in the male rat pituitary gland. Journal of Molecular Endocrinology 53(2), pp. 271-280. (10.1530/JME-14-0158) pdf Kropivšek, K., Pickford, J. and Carter, D. A. 2013. Postnatal dynamics of Zeb2 expression in rat brain: analysis of novel 3' UTR sequence reveals a miR-9 interacting site. Journal of Molecular Neuroscience 52(1), pp. 138-147. (10.1007/s12031-013-0146-x) El-Kasti, M. M., Wells, T. and Carter, D. A. 2012. A novel long-range enhancer regulates postnatal expression of Zeb2: implications for Mowat-Wilson syndrome phenotypes. Human Molecular Genetics 21(26), pp. 5429-5442. (10.1093/hmg/dds389) Bustos, D.et al. 2011. Global daily dynamics of the pineal transcriptome. Cell and Tissue Research 344(1), pp. 1-11. (10.1007/s00441-010-1094-1) Davies, J. S., Klein, D. C. and Carter, D. A. 2011. Selective genomic targeting by FRA-2/FOSL2 transcription factor: Regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/creb-binding protein (CBP) mechanism. Journal of Biological Chemistry 286(17), pp. 15227-15239. (10.1074/jbc.M110.201996) Carter, D. A., Rough, K. and Wells, T. 2011. Transcription mapping of embryonic rat brain reveals EGR-1 induction in SOX2+ neural progenitor cells. Frontiers in Molecular Neuroscience 4 (10.3389/fnmol.2011.00006) Klein, D.et al. 2010. Pineal function: impact of microarray analysis. Molecular and Cellular Endocrinology 314(2), pp. 170-183. (10.1016/j.mce.2009.07.010) Cope, D.et al. 2009. Enhanced tonic GABA(A) inhibition in typical absence epilepsy. Nature Medicine 15(12), pp. 1392-1398. (10.1038/nm.2058) Fustin, J.et al. 2009. Egr1 involvement in evening gene regulation by melatonin. Faseb Journal 23(3), pp. 764-773. (10.1096/fj.08-121467) Bailey, M.et al. 2009. Night/day changes in pineal expression of >600 genes central role of adrenergic/cAMP signaling. Journal of Biological Chemistry 284(12), pp. 7606-7622. (10.1074/jbc.M808394200)