BéruBé, Kelly - Cardiff University

个人简介

Dr Kelly BéruBé is the Director of the Lung & Particle Research Group at the School of Biosciences, Cardiff University, UK. With a background in electron microscopy and lung toxicology, she has built an international reputation in the field air pollution and human health and holds numerous appointments in the USA and UK on funding bodies, advisory councils, professional societies and journal editorial boards that focus on environmental health. Her research focuses on the determination of intelligent biomarkers of exposure and harm in the respiratory system, with a particular interest in understanding how pollutants compromise lung biochemistry and alter gene and protein expression to drive disease mechanisms. Dr BéruBé's research has been recognised with a number of awards, including the Institute for Science & Health (USA) 'Scientific Merit Award 2006' for toxicogenomics of inhaled xenobiotics and the honour of being the British Toxicology Society 'Australasia Visitor 2006' to conduct a coast-to-coast lecture tour on nano-toxicology. Current work on 'human tissue equivalents of respiratory epithelia', as viable in vitro alternatives to animals for in vivo inhalation toxicology, was awarded the UK NC3Rs/MRC 'Replacement Prize' and the 'Science & Technology Innovation Prizes' in 2007 and 2010 and 2012. In 2013, her Metabo-Lung™ and Micro-Lung™ models won the prestigious international Lush 'Science Prize' for 3Rs research. Dr BéruBé's field of study is of natural interest to the general public, and as such, she is a prolific science writer and popular invited-speaker, and has worked extensively on communicating her research through public engagements of science for primary schools, laymen groups and professional learned societies. She is currently a feature scientist on the BBC children's science television show called 'Operation Ouch!'

研究领域

The Lung & Particles Research Group (LPRG) specialises in 'Molecular Environmental Health'. The principal research focus is the determination of intelligent biomarkers of exposure and harm in the human respiratory system following exposure to aerial xenobiotics. Our particular interest lies in understanding how pollutants (e.g. man-made, biological, natural and industrial) compromise lung biochemistry/metabolism and alter gene and protein expression to drive disease mechanisms. Our key research tool involves the generation of human tissue equivalents of the respiratory epithelia, derived from the stem cell niche of patient donor tissue samples, as an alternative platform to animal models.

近期论文

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Shao, L.et al. 2017. Seasonal variation of particle-induced oxidative potential of airborne particulate matter in Beijing. Science of the Total Environment 579, pp. 1152-1160. (10.1016/j.scitotenv.2016.11.094) Shao, L.et al. 2016. The oxidative potential of PM10 from coal, briquettes and wood charcoal burnt in an experimental domestic stove. Atmospheric Environment 127, pp. 372-381. (10.1016/j.atmosenv.2015.12.007) pdf Shao, L.et al. 2016. Season variation of particle-induced oxidative potential of airborne particulate matter in Beijing. Stoten pdf BéruBé, K. A. and Redmond, C. 2016. The 2015 Lush Prize awards [Editorial]. ATLA Alternatives to Laboratory Animals 44, pp. 401-406. Chuang, H.et al. 2015. Characterization of pulmonary protein profiles in response to zinc oxide nanoparticles in mice: a 24-hour and 28-day follow-up study. International Journal of Nanomedicine , pp. 4705-4716. (10.2147/IJN.S82979) pdf Oeder, S.et al. 2015. Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions. PLoS ONE 10(6), article number: e0126536. (10.1371/journal.pone.0126536) pdf Moreno, T.et al. 2015. A new look at inhalable metalliferous airborne particles on rail subway platforms. Science of the Total Environment 505, pp. 367-375. (10.1016/j.scitotenv.2014.10.013) pdf Prytherch, Z. C. and Berube, K. A. 2014. A normal and biotransforming model of the human bronchial epithelium for the toxicity testing of aerosols and solubilised substances. Alternatives to Laboratory Animals: ATLA 42(6), pp. 377-381. Prytherch, Z. C. and Berube, K. A. 2014. A normal and biotransforming model of the human bronchial epithelium for the toxicity testing of aerosols and solubilised substances. Alternatives to Laboratory Animals 42(6), pp. 377-381. Berube, K. A. and Redmond, C. 2014. The 2013 Lush Prize awards [Editorial]. ATLA: Alternatives to Laboratory Animals 41(6) Price, H.et al. 2014. Comparison of instruments for particle number size distribution measurements in air quality monitoring. Journal of Aerosol Science 76, pp. 48-55. (10.1016/j.jaerosci.2014.05.001) Lui, W.et al. 2014. Physicochemical and biological characterisation of single-walled and double-walled carbon nanotubes in biological media. Journal of Hazardous Materials 280, pp. 216-225. (10.1016/j.jhazmat.2014.07.069) Xiao, Z.et al. 2014. A toxicological study of inhalable particulates in an industrial region of Lanzhou City, northwestern China: results of a plasmid scission assay. Aeolian Research 14, pp. 25-34. (10.1016/j.aeolia.2014.03.004)