Buchman, Vladimir - Cardiff University

研究领域

A principal goal of our research is to understand molecular mechanisms involved in pathogenesis of certain human neurodegenerative and metabolic diseases. Currently we focus on studies of normal function of several protein families and dysfunction of family members linked to human pathologies. Various experimental approaches ranging from in vitro macromolecule interactions to production and phenotypical characterisation of animal models are used in these studies.

近期论文

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Shelkovnikova, T.et al. 2017. Elevated pre-stress p-eIF2a levels impair stress granule assembly in neurons in vitro and in vivo. Scientific Reports- Faculty of Agriculture Okayama University pdf Roman, A.et al. 2016. Generation of mouse lines with conditionally or constitutively inactivated Snca gene and Rosa26-stop-lacZ reporter located in cis on the mouse chromosome 6. Transgenic Research (10.1007/s11248-016-9995-8) pdf Ludtmann, M.et al. 2016. Monomeric alpha-synuclein exerts a physiological role on brain ATP synthase. Journal of Neuroscience 36(41), pp. 10510-10521. (10.1523/JNEUROSCI.1659-16.2016) pdf Khatlani, T.et al. 2016. A novel interaction of the catalytic subunit of protein phosphatase 2A with the adaptor protein CIN85 suppresses phosphatase activity and facilitates platelet outside-in ?IIb?3Integrin Signaling. The Journal of Biological Chemistry 291(33), pp. 17360-17368. (10.1074/jbc.M115.704296) Connor-Robson, N.et al. 2016. Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism. Neurobiology of Aging 46, pp. 107-112. (10.1016/j.neurobiolaging.2016.06.020) pdf Fares, M.et al. 2016. Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 113(7), pp. E912-E921. (10.1073/pnas.1512876113) pdf Ninkina, N.et al. 2015. A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression. Scientific Reports 5, article number: 16615. (10.1038/srep16615) pdf Machhada, A.et al. 2015. Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve. Heart Rhythm 12(11), pp. 2285-2293. (10.1016/j.hrthm.2015.06.005) Abramycheva, N.et al. 2015. C9ORF72 hexanucleotide repeat expansion in ALS patients from the Central European Russia population. Neurobiology of Aging 36(10), pp. 2908.e5-2908.e9. (10.1016/j.neurobiolaging.2015.07.004) pdf Robinson, H.et al. 2015. Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16(5-6), pp. 402-409. (10.3109/21678421.2015.1040994)