Blain, Emma - Cardiff University - School of Biosciences

个人简介

1995-1998 BSc (1st Class Hons) Biochemistry with Medical Biochemistry (Cardiff) 1998-2002 PhD (BBSRC CASE Award with Amersham Biosciences, Cardiff)

研究领域

My research interests encompass the cellular and molecular events that are involved in maintaining articular cartilage tissue homeostasis, and the mechanism/s that propagate degeneration of the tissue as observed in the pathology of osteoarthritis. Osteoarthritis is a multi-factorial disease and one of the major risk factors is abnormal mechanical load i.e. through sports injury, obesity. Affiliated with the Arthritis Research UK Biomechanics and Bioengineering Centre, I manage the mechanical loading laboratory in the School of Biosciences (Figure 1), where my research area is the identification of signalling pathways that mediate either anabolic or catabolic responses in connective tissues, in particular articular cartilage. Collectively, the aims of my research and the projects that I am currently involved in are to (1) identify novel mechanotransduction pathways that influence cartilage chondrocyte homeostasis, (2) understand the underlying mechanisms of cartilage destruction propagated by abnormal mechanical load, and (3) identify targeted interventions to delay/halt osteoarthritis progression.

近期论文

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Al-Sabah, A.et al. 2016. Importance of reference gene selection for articular cartilage mechanobiology studies. Osteoarthritis and Cartilage 24(4), pp. 719-730. (10.1016/j.joca.2015.11.007) pdf Khatib, N.et al. 2016. Developing an in vitro model of healthy and OA medial knee compartmental loading. Osteoarthritis and Cartilage 24(Supp 1), pp. S344. (10.1016/j.joca.2016.01.617) Wyatt, H.et al. 2016. Variation in electrosurgical vessel seal quality along the length of a porcine carotid artery. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 230(3), pp. 169-174. (10.1177/0954411915621092) pdf Ali, A.et al. 2015. Anti-metastatic and cytotoxic properties of frankincense and scented myrrh. Anticancer Research 35(7), pp. 4310-4311. Li, S.et al. 2014. Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS ONE 9(10), article number: e109536. (10.1371/journal.pone.0109536) pdf Gilbert, S.et al. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078) Blain, E. J., Thomas, R. S. and Duance, V. C. 2012. Effect of Wnt3A on load-induced markers of chondrocyte matrix metabolism. International Journal of Experimental Pathology 93(4), pp. A13-A14. (10.1111/j.1365-2613.2012.00822.x) Gilbert, S.et al. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57. Khan, I.et al. 2011. Fibroblast growth factor 2 and transforming growth factor β1 induce precocious maturation of articular cartilage. Arthritis & Rheumatism 63(11), pp. 3417-3427. (10.1002/art.30543) Dachtler, J.et al. 2011. Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. Journal of Neuroscience 31(31), pp. 11220-11230. (10.1523/JNEUROSCI.1590-11.2011) pdf Li, S.et al. 2011. The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study. European Cells and Materials 21, pp. 508-522. Thomas, R.et al. 2011. Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Research and Therapy 13(6), article number: R203. (10.1186/ar3536) pdf