Zubair, Hassan - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

个人简介

I have obtained my doctorate in metabolomics by investigating plant-pathogen interactions using Brachypodium distachyon as model grass specie and rice blast fungus (Magnaporthe grisea) as a pathogen.

研究领域

Working in the metabolomics group, I am interested in developing standardised protocols for metabolomics analysis using a variety of MS instruments. Techniques used in the High Resolution Metabolomics Laboratory include, high throughput metabolite fingerprinting using both nominal mass - and ultra-high resolution - Flow Infusion Electrospray Ionization - Mass Spectrometry (FIE-MS), accurate mass analysis using Fourier Transform Ion Cyclotron Resonance MS (FT-ICR-MS), High Performance Liquid Chromatography (HPLC), Liquid Chromatography MS (LC-MS), Ultra High Performance Liquid Chromatography MS (UHPLC-MS), Gas Chromatography MS (GC-MS), and Triple Quadrupole MS (QQQ-MS). I am interested in the analysis of food/nutritional biomarkers from urine and plasma samples by metabolite fingerprinting technique combined with supervised multivariate data analysis methods (e.g. Principal Components Analysis, Linear Discriminant Analysis, Random Forest, etc) and by using accurate mass signal annotation tool (MZedDB), as well as quantification of these biomarkers using QQQ-MS to accurately monitor metabolic changes in response to both acute and habitual dietary exposure.

近期论文

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López-Álvarez, D., Zubair, H., Beckmann, M., Draper, J., Catalán, P. 2017. Diversity and association of phenotypic and metabolomic traits in the close model grasses Brachypodium distachyon, B. stacei and B. hybridum. Annals of Botany 119 (4) pp. 545-561. Wilson, T., Willis, N.D., Zubair, H., Beckmann, M., Xie, L., Tailliart, K., Lloyd, A., Mathers, J.C., Draper, J. 2016. Developing community-based urine sampling methods to facilitate dietary exposure biomarker technology for population assessment. Proceedings of the Nutrition Society 75 (OCE3) E240 Nutrition Society Summer Meeting, Dublin, United Kingdom of Great Britain and Northern Ireland, 11/07/2016 - 14/07/2016. Lloyd, A.J., Zubair, H., Willis, N.D., Wilson, T., Xie, L., Tailliart, K., Chambers, E.S., Garcia-Perez, I., Holmes, E., Frost, G., Mathers, J.C., Beckmann, M., Draper, J. 2016. Quantification of dietary biomarkers in spot urine samples reflects the intake of foods of UK high public health importance. Proceedings of the Nutrition Society 75 (OCE3) E248 Nutrition Society Summer Meeting, Dublin, United Kingdom of Great Britain and Northern Ireland, 11/07/2016 - 14/07/2016. Draper, J., Rasmussen, S., Zubair, H. 2011. Metabolite analysis and metabolomics in the study of biotrophic interactions between plants and microbes. In R. D. Hall. (ed) Annual Plant Reviews. Wiley pp. 25-59. Draper, J., Enot, D.P.L., Parker, D.A., Beckmann, M., Snowdon, S., Lin, W., Zubair, H. 2009. Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'. BMC Bioinformatics 10 (227) 227 Cadair Parker, D.A., Beckmann, M., Zubair, H., Enot, D.P.L., Caracuel-Rios, Z., Overy, D.P., Snowdon, S., Talbot, N.J., Draper, J. 2009. Metabolomic analysis reveals a common pattern of metabolic re-programming during invasion of three host plant species by Magnaporthe grisea. Plant Journal 59 (5) pp. 723-737. Cadair