Shah, Ifat - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

个人简介

I received my PhD at the University of Bath (England, UK), in 2001 on a thesis entitled "Novel Hypoxia-Selective Prodrugs of Radiosensitisers and Chemosensitisers" under the supervision of Professor Mike D. Threadgill (Department of Pharmacy and Pharmacology) and Dr. William J. D. Whish (Department of Biology and Biochemistry). I joined IGER in 2002 as the post-doctoral researcher on a BBSRC-LINK project (Phytochemical library from British plants 2002-2004) with a pharmaceutical industrial partner (Molecular Nature Ltd.) on the isolation and identification of natural plant products. This enabled me to expand my skills into natural product chemistry, following my PhD studies in which I trained as a synthetic medicinal chemist focusing on design, synthesis and evaluation of drugs for cancer therapy. In 2004, I was made principal investigator on a metabolomics project to develop a pre-mortem diagnostic test for transmissible spongiform encepathalopathy (TSE) diseases in sheep and cattle. I have since also worked on a project concerned with utilising a metabolomics approach to improve animal health and performance. In April 2008, I joined the Biorenewables and Environmental Change division at IBERS.

研究领域

Green Biotechnology: High value chemicals to improve plant and human health. Antimicrobials from extremophiles. Rhizosphere and endophytic microbes to identify metabolites that promote plant growth or trigger plant defence. Identification of chemical markers linked to key traits relevant for the biorefining industry: Chemicals in Miscanthus and oats, which are active against pests such as nematodes and pathogens and link these to specific QTLs. Characterisation of cell wall chemistry: Synthesis of diferulates using novel synthetic routes in order to develop monoclonal antibodies characterisation of cell walls and synthesis of chromogenic substrates for identification and quantification of cell-wall enzymes.

近期论文

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Belanche Gracia, A., Jones, E.L., Shah, I., Newbold, C. 2016. A metagenomics approach to evaluate the impact of dietary supplementation with Ascophyllum nodosum or Laminaria digitata on rumen function in Rusitec fermenters. Frontiers in Microbiology 7 299 Cadair Shah, I., Donnison, I., Insole, J., Winters, A., Dalton, S., Woodman, T., Bosch, M., Threadgill, M.D. 2016. (In press) An efficient assay for ferulic acid esterase and para-coumaric acid esterases in plants at physiologically relevant activities. Cell Chemistry and Biology 6 (5) pp. 300-311. Mohammad, R.H., Nur e-Alam, M., Lahman, M., Shah, I., Tizzard, G.J., Coles, S.J., Fowler, M., Drake, A.F., Heyes, D., Thoss, V. 2016. Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome. Phytochemistry 128 pp. 82-94. Parveen, I., Wilson, T., Threadgill, M.D., Luyten, J., Roberts, R.E., Robson, P.R., Hauck, B.D., Donnison, I.S., Winters, A.L. 2014. Screening for potential co-products in a Miscanthus sinensis mapping family by liquid chromatography with mass spectrometry detection. Phytochemistry 105 pp. 186-196. Parveen Shah, I., Wilson, T., Donnison, I.S., Cookson, A.R., Hauck, B.D., Threadgill, M.D. 2013. Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus. Phytochemistry 92 pp. 160-167. Parveen, I., Threadgill, M.D., Hauck, B.D., Donnison, I.S., Winters, A.L. 2011. Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus x giganteus using LC-ESI-MS(n). Phytochemistry 72 (18) pp. 2376-2384. Parveen, I., Threadgill, M.D., Hauck, B.D., Donnison, I., Winters, A.L. 2011. Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus × giganteus using LC–ESI-MSn. Phytochemistry 72 (18) pp. 2376-2384. Hauck, B.D., Parveen, I., Gallagher, J.A., Donnison, I.S., Winters, A. 2010. Accumulation of soluble phenolic compounds in the forage grass species, cocksfoot (Dactylis glomerata L). XXVth International Conference on Polyphenols, Montpellier, France, 24/08/2010 - 27/08/2010. pp. T2.03.