Nibau, Candida - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

个人简介

I received my PhD at the University of Massachusetts, Amherst, USA, in 2005 on a thesis entitled 'The role of the Arabidopsis small GTPase Arac7 (ROP9) in hormone signaling', under supervision of Prof. Alice Cheung. In 2005 I moved to the UK for my first postdoctoral position to join the lab of Dr. Juliet Coates where I studied the role of Arabidillo proteins during lateral root formation in Arabidopsis. In October 2008 I moved to Aberystwyth University to join Dr. Glyn Jenkins' lab as a technician on the Barley Meiosis LoLa project. Since 2012 I have been working as a Post-doc in the lab of Prof. John Doonan.

研究领域

In order to survive in an ever changing environment, plants have to be able to monitor changes in the environment and adapt their development programs accordingly. I am interested in the signaling pathways triggered in the plant in response to external and endogenous stimuli and how these pathways affect plant growth and development. During my PhD work I looked at the role of small G proteins as signal transducers to plant hormones that regulate many aspects of development. My post-doctoral work focused on some of the downstream molecules activated by specific developmental programs triggered during lateral root formation in Arabidopsis. In particular, I studied the role Arabidillo proteins during lateral root initiation and established that Arabidillo protein stability is regulated by proteasome-dependent degradation and this is important for its function during lateral root initiation. In the lab of Dr. Glyn Jenkins using cytogenetical techniques we developed a recombination map in barley. This allowed us to test the effect of different stimuli and the loss of specific meiotic proteins on the recombination process in barley. My current project in Prof. Doonan's lab involves the study of cyclin-dependent kinases and how they affect male meiosis at higher temperatures. Male meiosis and recombination are very sensitive to temperature changes and this affects plant fitness and yield. Understanding the pathways behind temperature sensing and meiosis in plants will help to inform the breeding of crops better suited for an ever-changing climate.

近期论文

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Doonan, J., Boyle, R., Han, J., Williams, K.S., Alcalde Barrios, A., Strange, H., Corke, F., Nibau, C., Scotson, C.P., Camargo-Rodriguez, A., Zwiggelaar, R., Sturrock, C., Mooney, S. 2016. Image-based phenotyping to measure plant diversity and performance. Plant and Animal Genome Conference XXIV, San Diego, California, United States of America, 09/01/2016 - 13/01/2016. Bush, M.S., Pierrat, O., Nibau, C., Mikitova, V., Zheng, T., Corke, F.M.K., Vlachonasios, K., Mayberry, L.K., Browning, K.S., Doonan, J. 2016. eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and is Modulated by Phosphorylation. Plant Physiology 172 (1) pp. 128-140. Cadair Phillips, D., Jenkins, G., Macaulay, M., Nibau, C., Wnetrzak, J., Fallding, D.S., Colas, I., Oakey, H., Waugh, R., Ramsay, L. 2015. The effect of temperature on the male and female recombination landscape of barley. New Phytologist 208 (2) pp. 421-429. Gibbs, D.J., Voß, U., Harding, S.A., Fannon, J., Moody, L.A., Yamada, E., Swarup, K., Nibau, C., Bassel, G.W., Choudhary, A., Lavenus, J., Bradshaw, S.J., Stekel, D.J., Bennett, M.J., Coates, J.C. 2014. AtMYB93 is a novel negative regulator of lateral root development in Arabidopsis. New Phytologist 203 (4) pp. 1194-207. Cadair Zheng, T., Nibau, C., Phillips, D.W., Jenkins, G., Armstrong, S.J., Doonan, J.H. 2014. CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America 111 (6) pp. 2182-2187. Cadair Phillips, D.W., Wnetrzak, J., Nibau, C.S., Barakate, A., Ramsay, L., Wright, F., Higgins, J.D., Perry, R.M., Jenkins, G. 2013. Quantitative high resolution mapping of HvMLH3 foci in barley pachytene nuclei reveals a strong distal bias and weak interference. Journal of Experimental Botany 64 (8) pp. 2139-2154. Nibau, C., Tao, L., Levasseur, K., Wu, H., Cheung, A.Y. 2013. The Arabidopsis small GTPase AtRAC7/ROP9 is a modulator of auxin and abscisic acid signalling. Journal of Experimental Botany 64 (11) pp. 3425-3437.