Mur, Luis - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

研究领域

In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare). My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome. My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains. I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

O'shea, K., Cameron, S.J., Lewis, K.E., Lewis, P.D., Lu, C., Mur, L.A. 2017. Corrigendum to Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study [Biochimica et Biophysica Acta (BBA) – General subjects, vol. 1860 (2016), pp. 2682–2687]. Biochimica et Biophysica Acta (BBA) - General Subjects Guo, Q., Meng, L., Humphreys, M.W., Scullion, J., Mur, L.A. 2017. Expression of FlHMA3, a vacuolar P1B2-ATPase from Festulolium loliaceum, correlates with response to cadmium stress. Plant Physiology and Biochemistry 112 pp. 270-277. Sivakumaran, A., Akinyemi, A., Mandon, J., Cristescu, S.M., Hall, M., Harren, F.J.M., Mur, L. 2016. ABA Suppresses Botrytis cinerea Elicited NO Production in Tomato to Influence H2O2 Generation and Increase Host Susceptibility. Frontiers in Plant Science 7 709 Cadair Sánchez-Martín, J., Montilla-Bascón, G., Mur, L.A.J., Rubiales, D., Prats, E. 2016. Compromised Photosynthetic Electron Flow and H2O2 Generation Correlate with Genotype-Specific Stomatal Dysfunctions during Resistance against Powdery Mildew in Oats. Frontiers in Plant Science 7 1660 Cadair Aiswarya, G., Mallika, V., Mur, L., Soniya, E.V. 2016. Ectopic expression and functional characterization of type III polyketide synthase mutants from Emblica officinalis Gaertn. Plant Cell Reports 35 (10) pp. 2077-2090. Mandon, J., Mur, L.A.J., Harren, F.J.M., Cristescu, S.M. 2016. Laser-Based Methods for Detection of Nitric Oxide in Plants. In K. J. Gupta. (ed) Plant Nitric Oxide: Methods and Protocols. Methods in Molecular Biology, vol. 1242 Springer Nature pp. 113-126. Fisher, L., Han, J., Corke, F., Akinyemi, A., Didion, T., Nielsen, K.K., Doonan, J., Mur, L., Bosch, M. 2016. Linking dynamic phenotyping with metabolite analysis to study natural variation in drought responses of Brachypodium distachyon. Frontiers in Plant Science 7 1751 Cadair Cook, J.M., Edwards, A., Bulling, M., Mur, L.A.J., Cook, S., Gokul, J.K., Cameron, K.A., Sweet, M., Irvine-Fynn, T.D.L. 2016. Metabolome-mediated biocryomorphic evolution promotes carbon fixation in Greenlandic cryoconite holes. Environmental Microbiology 18 (Thematic Issue) pp. 4674-4686. O'Shea, K., Cameron, S.J.S., Lewis, K.E., Lewis, P.D., Lu, C., Mur, L.A.J. 2016. Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study. Biochimica et Biophysica Acta (BBA) - General Subjects 1860 (11) pp. 2682-2687.