Morphew, Russ - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

研究领域

Current research is aimed at utilising modern high resolution proteomic technologies and mass spectrometry to investigate protein function and interactions. This work has focussed upon microbial-host interactions and the proteins that act upon this interface. In particular, how proteins can facilitate the invasion, establishment or colonisation of an organism within a host. Present research focuses upon the interaction of ruminant bacteria upon ingested forage using proteomics to uncover proteins involved in bacterial colonisation, plant protein degradation and the metabolic pathways involved. Also of interest are parasitic helminths of economic importance including the liver flukes Fasciola hepatica and F. gigantica, nematodes Haemonchus contortus and Teladorsagia circumcincta and the model nematode Caenorhabditis elegans. Recent research using high resolution proteomics has focussed upon vaccine discovery and the development and response to anthelmintic stress and metabolism. The main driver of future research is to increase our understanding of how proteins interact with other proteins within the same organism, between organisms, within a host or with a forage. How proteins interact with ligands such as anthelmintics and metabolites are also of interest, including how proteins function in the metabolism and action of anthelmintics and ultimately anthelmintic resistance.

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McCammick, E., McVeigh, P., McCusker, P., Timson, D., Morphew, R., Brophy, P., Marks, N., Mousley, A., Maule, A. 2016. Calmodulin disruption impacts growth and motility in juvenile liver fluke. Parasites & Vectors 9 46 Cadair Morphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S.M., Saifullah, K., Raman, M., Ravikumar, G., LaCourse, E.J., Maule, A.G., Brophy, P. 2016. Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species. Journal of Proteome Research 15 (9) pp. 3308-3321. Hart, E., Onime, L.A., Davies, T., Morphew, R., Kingston-Smith, A. 2016. The effects of PPO activity on the proteome of ingested red clover and implications for improving the nutrition of grazing cattle. Journal of Proteomics 141 pp. 67-76. Cadair Huson, K.M., Brophy, P., Morphew, R., MacKintosh, N. 2015. Identification of the rumen fluke Calicophoron daubneyi infecting cattle in Wales. Advances in Animal Biosciences 6 (Special Issue 02) Proceedings of the British Society of Animal Science, Chester, United Kingdom of Great Britain and Northern Ireland, 14/04/2015 - 15/04/2015. pp. 183. Morphew, R.M., MacKintosh, N.D., Hart, E.H., Prescott, M., LaCourse, E.J., Brophy, P.M. 2014. In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatment. EuPA Open Proteomics 3 pp. 85-99. Cadair McVeigh, P., McCammick, E., McCusker, P., Morphew, R.M., Mousley, A., Abidi, A., Saifullah, K.M., Muthusamy, R., Gopalakrishnan, R., Spithill, T.W., Dalton, J.P., Brophy, P.M., Marks, N.J., Maule, A.G. 2014. RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitro. PLoS Neglected Tropical Diseases 8 (9) 0003185 Cadair Ahammed Shareef, P.A., Brennan, G.P., McVeigh, P., Hannan Khan, M.A., Morphew, R.M., Mousley, A., Marks, N.J., Khalid Saifullah, M.K., Brophy, P.M., Maule, A.G., Abidi, S.M.A. 2014. Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goat. Acta Tropica 136 pp. 108-117. Morphew, R.M., Hamilton, C.M., Wright, H.A., Dowling, D.J., O'Neill, S.M., Brophy, P.M. 2013. Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica resleased by Nonident P40. Veterinary Parasitology 191 (3-4) pp. 379–385. Cadair