Lloyd, Amanda - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

研究领域

Together with Prof John Draper and Dr Manfred Beckmann I am interested in developing standardised protocols for nutritional metabolomics investigations for monitoring metabolic changes in response to both acute and habitual dietary exposure. Techniques employed includes high throughput metabolomic fingerprinting based on Flow Infusion Electrospray Ionization-Mass Spectrometry (FIE-MS), accurate mass analysis using Fourier-Transform Ion Cyclotron Resonance Ultra MS (FT-ICR-MS) in conjunction with supervised multivariate data analysis (Principal Components Analysis, Linear Discriminant Analysis, Area Under the (Receiver operating characteristic) curve (AUC), and Random Forest) and ESI-MS signal annotation tools

近期论文

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Lloyd, A., Beckmann, M., Wilson, T., Tailliart, K., Allaway, D., Draper, J. 2017. Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry plasma lipidomics can distinguish between canine breeds despite uncontrolled environmental variability and non-standardized diets: Plasma lipidome of dog breeds using UHPLC-HRM. Metabolomics 13 15 Cadair Beckmann, M., Joosen, A.M., Clarke, M.M., Mugridge, O., Frost, G., Engel, B., Tailliart, K., Lloyd, A., Draper, J., Lodge, J.K. 2016. Changes in the human plasma and urinary metabolome associated with acute dietary exposure to sucrose and the identification of potential biomarkers of sucrose intake. Molecular Nutrition and Food Research 60 (2) pp. 444-457. Cadair Lloyd, A., Beckmann, M., Tailliart, K., Brown, W.Y., Draper, J., Allaway, D. 2016. Characterisation of the main drivers of intra- and inter- breed variability in the plasma metabolome of dogs. Metabolomics 12 (4) 72 Cadair Wilson, T., Willis, N.D., Zubair, H., Beckmann, M., Xie, L., Tailliart, K., Lloyd, A., Mathers, J.C., Draper, J. 2016. Developing community-based urine sampling methods to facilitate dietary exposure biomarker technology for population assessment. Proceedings of the Nutrition Society 75 (OCE3) E240 Nutrition Society Summer Meeting, Dublin, United Kingdom of Great Britain and Northern Ireland, 11/07/2016 - 14/07/2016. Lloyd, A.J., Zubair, H., Willis, N.D., Wilson, T., Xie, L., Tailliart, K., Chambers, E.S., Garcia-Perez, I., Holmes, E., Frost, G., Mathers, J.C., Beckmann, M., Draper, J. 2016. Quantification of dietary biomarkers in spot urine samples reflects the intake of foods of UK high public health importance. Proceedings of the Nutrition Society 75 (OCE3) E248 Nutrition Society Summer Meeting, Dublin, United Kingdom of Great Britain and Northern Ireland, 11/07/2016 - 14/07/2016. Lloyd, A.J., Beckmann, M., Haldar, S., Seal, C., Brandt, K., Draper, J. 2013. Data-driven strategy for the discovery of potential urinary biomarkers of habitual dietary exposure. American Journal of Clinical Nutrition 97 (2 ) pp. 377-389. Beckmann, M., Lloyd, A., Halder, S., Fave, G., Seal, C., Brandt, K., Mathers, J.C., Draper, J. 2013. Dietary exposure biomarker-lead discovery based on Metabolomics analysis of urine samples. Proceedings of the Nutrition Society 72 (3) pp. 352-361. Cadair