Chalmers, Iain - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

个人简介

2013-present Lecturer in Veterinary Biosciences, IBERS, Aberstwyth University, UK 2010-2013 EU-funded Post-Doctoral Research Associate, IBERS, Aberystwyth University, UK 2008-2009 Research Technician, IBERS, Aberystwyth University, UK 2002-2009 Wellcome Trust PhD programme, under supervision of Dr. Karl Hoffmann, Department of Pathology, University of Cambridge, UK 1998-2002 BSc (Hons.) Degree in Immunology, Edinburgh University, UK

研究领域

My research focuses on the identification and characterisation of helminth proteins essential to the parasites survival in the host. The aim of this research is to discover novel vaccine candidates/drug targets and to also gain a deeper understanding of host/parasite interactions. Using bioinformatic approaches, my research also examines the evolution of gene families (such as the SmVAL family) across parasitic and non-parasitic species.

近期论文

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Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R.A., Pierrot, C., Khalife, J., Grevelding, C.G., Chalmers, I.W., Yazdanbakhsh, M., Hoffmann, K.F., Hokke, C.H., Haas, H., Schramm, G. 2015. Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7. PLoS Neglected Tropical Diseases 9 (3) e0003593 Cadair Chalmers, I.W., Fitzsimmons, C.M., Brown, M., Pierrot, C., Jones, F.M., Wawrzyniak, J.M., Fernandez-Fuentes, N., Tukahebwa, E.M., Dunne, D.W., Khalife, J., Hoffmann, K.F. 2015. Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. PLoS Neglected Tropical Diseases 9 (7) pp. e0003920. Cadair Farnell, E.J., Tyagi, N., Ryan, S., Chalmers, I.W., Pinot de Moira, A., Jones, F.M., Wawrzyniak, J., Fitzsimmons, C.M., Tukahebwa, E.M., Furnham, N., Maizels, R.M., Dunne, D.W. 2015. Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection. Frontiers in Immunology 6 pp. 26. Cadair Yoshino, T.P., Brown, M., Wu, X., Jackson, C.J., Ocadiz-Ruiz, R., Chalmers, I.W., Kolb, M., Hokke, C.H., Hoffmann, K.F. 2014. Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression. International Journal for Parasitology 44 (8) pp. 551-563. Cadair Geyer, K.K., Chalmers, I.W., MacKintosh, N.D., Hirst, J.E., Geoghegan, R., Badets, M., Brophy, P.M., Brehm, K., Hoffmann, K.F. 2013. Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes. BMC Genomics 14 462 Cadair Chalmers, I.W., Hoffmann, K.F. 2012. Platyhelminth venom allergen-like (VAL) proteins: revealing structural diversity, class specific features and biological associations across the phylum. Parasitology 139 (10) pp. 1231-1245. Fitzsimmons, C.M., Jones, F.M., Stearn, A., Chalmers, I.W., Hoffmann, K.F., Wawrzyniak, J., Wilson, S., Kabatereine, N.B., Dunne, D.W. 2012. The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Neglected Tropical Diseases 6 (4) e1593 Cadair