Brophy, Peter - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

研究领域

My main research interest is to resolve using functional genomics how liver and rumen fluke parasites interact with their respective host environments. To date, new parasite proteins have been discovered to support drug and vaccine development and diagnostics . I am also interested in developing new molecular tools to measure anthelmintic resistance in liver fluke and a protein biomarker panel has been identified to measure Triclabendazole (TCBZ) failure and resistance for new laboratory and faecal based field tests.

近期论文

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Jones, R., Williams, H., Dalesman, S., Sinmidele, A., Thomas, R.K., Brophy, P. 2017. The prevalence and development of digenean parasites within their intermediate snail host, Galba truncatula, in a geographic area where the presence of Calicophoron daubneyi has recently been confirmed. Veterinary Parasitology McCammick, E., McVeigh, P., McCusker, P., Timson, D., Morphew, R., Brophy, P., Marks, N., Mousley, A., Maule, A. 2016. Calmodulin disruption impacts growth and motility in juvenile liver fluke. Parasites & Vectors 9 46 Cadair Morphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S.M., Saifullah, K., Raman, M., Ravikumar, G., LaCourse, E.J., Maule, A.G., Brophy, P. 2016. Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species. Journal of Proteome Research 15 (9) pp. 3308-3321. Jones, R., Brophy, P., Mitchell, E.S., Williams, H. 2016. Rumen fluke Calicophoron daubneyi on Welsh farms: Prevalence, risk factors, and observations on co-infection with Fasciola hepatica. Parasitology pp. 237-247. Cadair Hart, E., Brophy, P., Prescott, M., Bartley, D.J., Wolf, B., Hamilton, J.V. 2015. A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: Case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus. Veterinary Parasitology 207 (3-4) pp. 266-275. Jones, R., Williams, H., Dalesman, S., Brophy, P. 2015. Confirmation of Galba truncatula as an intermediate host snail forCalicophoron daubneyi in Great Britain, with evidence of alternative snail species hosting Fasciola hepatica. Parasites & Vectors 8 (656) Cadair Huson, K.M., Brophy, P., Morphew, R., MacKintosh, N. 2015. Identification of the rumen fluke Calicophoron daubneyi infecting cattle in Wales. Advances in Animal Biosciences 6 (Special Issue 02) Proceedings of the British Society of Animal Science, Chester, United Kingdom of Great Britain and Northern Ireland, 14/04/2015 - 15/04/2015. pp. 183.