Beckmann, Manfred - Aberystwyth University - Institute of Biological, Environmental and Rural Sciences

个人简介

Dr Beckmann obtained his doctorate in analytical chemistry at the C.v.O. University Oldenburg, Germany, on the identification of pheromones in marine polychaetes. Since then he has contributed as a marine chemical ecologist to the understanding of chemical communication and antifouling (HKUST, Hongkong), to measure and estimate production of green house gases in wetlands (Cardiff University) and to the investigatigation of metabolic changes in GM-crops, during host-pathogen interactions and dietary effects on mammalian biofluids (Aberystwyth).

研究领域

Current research activities focus on Metabolomics: the non-targeted and comprehensive analysis of all metabolites in biological material detecting unforeseen metabolic changes. Metabolomics is the sum of a well designed and performed experiment, sampling strategies, sample preparation, instrumental analysis, raw data conversion, signal processing, data analysis, and data interpretation. The outcome of a Metabolomics experiment and interpretability of data very much depend on all members of a skilled team and their tools. In order to minimize sources of variability and bias, robust methods and protocols have been developed in a team effort orchestrated by Prof. John Draper at IBERS over the last 15 years, and are the subject of future activities.

近期论文

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López-Álvarez, D., Zubair, H., Beckmann, M., Draper, J., Catalán, P. 2017. Diversity and association of phenotypic and metabolomic traits in the close model grasses Brachypodium distachyon, B. stacei and B. hybridum. Annals of Botany 119 (4) pp. 545-561. Garcia-Perez, I., Posma, J.M., Gibson, R., Chambers, E.S., Hanson, T.H., Vestergaard, H., Hansen, T., Beckmann, M., Pedersen, O., Elliott, P., Stamler, J., Nicholson, J.K., Draper, J., Mathers, J.C., Holmes, E., Frost, G. 2017. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial. Lancet Diabetes and Endocrinology 5 (3) pp. 184-195. Cadair Lloyd, A., Beckmann, M., Wilson, T., Tailliart, K., Allaway, D., Draper, J. 2017. Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry plasma lipidomics can distinguish between canine breeds despite uncontrolled environmental variability and non-standardized diets: Plasma lipidome of dog breeds using UHPLC-HRM. Metabolomics 13 15 Cadair Garcia-Perez, I., Posma, J.M., Chambers, E.S., Nicholson, J.K., Mathers, J.C., Beckmann, M., Draper, J., Holmes, E., Frost, G. 2016. An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake. Journal of Agricultural and Food Chemistry 64 (11) pp. 2423-2431. Beckmann, M., Joosen, A.M., Clarke, M.M., Mugridge, O., Frost, G., Engel, B., Tailliart, K., Lloyd, A., Draper, J., Lodge, J.K. 2016. Changes in the human plasma and urinary metabolome associated with acute dietary exposure to sucrose and the identification of potential biomarkers of sucrose intake. Molecular Nutrition and Food Research 60 (2) pp. 444-457. Cadair Lloyd, A., Beckmann, M., Tailliart, K., Brown, W.Y., Draper, J., Allaway, D. 2016. Characterisation of the main drivers of intra- and inter- breed variability in the plasma metabolome of dogs. Metabolomics 12 (4) 72 Cadair Wilson, T., Willis, N.D., Zubair, H., Beckmann, M., Xie, L., Tailliart, K., Lloyd, A., Mathers, J.C., Draper, J. 2016. Developing community-based urine sampling methods to facilitate dietary exposure biomarker technology for population assessment. Proceedings of the Nutrition Society 75 (OCE3) E240 Nutrition Society Summer Meeting, Dublin, United Kingdom of Great Britain and Northern Ireland, 11/07/2016 - 14/07/2016. Lloyd, A.J., Zubair, H., Willis, N.D., Wilson, T., Xie, L., Tailliart, K., Chambers, E.S., Garcia-Perez, I., Holmes, E., Frost, G., Mathers, J.C., Beckmann, M., Draper, J. 2016. Quantification of dietary biomarkers in spot urine samples reflects the intake of foods of UK high public health importance. Proceedings of the Nutrition Society 75 (OCE3) E248 Nutrition Society Summer Meeting, Dublin, United Kingdom of Great Britain and Northern Ireland, 11/07/2016 - 14/07/2016.