个人简介

1997 PhD Analytical Chemistry Technical University of Berlin, Germany 1993 Diplom ~M.Sc. Chemistry Free University Berlin, Germany Awards Distinguished Scientist Award 2009, CCDG

研究领域

Comprehensive analyis of regulation of metabolism

The Fiehn research laboratory develops improved methods in analytical chemistry and bioinformatics to capture and utilize metabolomic data. These tools are employed to understand, which parts of larger biochemical networks respond to genetic perturbation or environmental stress. Metabolomics applications follow a two-tiered approach: they can be used for sample discrimination and classification (e.g. for clinical diagnostics or GMO substantial equivalence), or for biochemical and mechanistic studies (e.g. for understanding the onset and progression of human diseases, or for detailing regulatory modules in cells or subcellular compartments). Therefore, the Fiehn research laboratory uses several biological models on organismal, tissue or cellular level which are detailed in the Projects page.

近期论文

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Lee, Do Yup, Jeong-Jin Park, Dinesh K. Barupal, and Oliver Fiehn. "System response of metabolic networks in Chlamydomonas reinhardtii to total available ammonium." Molecular & Cellular Proteomics 11, no. 10 (2012): 973-988 Barupal, Dinesh K., Pradeep K. Haldiya, Gert Wohlgemuth, Tobias Kind, Shanker L. Kothari, Kent E. Pinkerton, and Oliver Fiehn. "MetaMapp: mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity." BMC bioinformatics 13, no. 1 (2012): 99 Davis MC, Fiehn O, and Durnford DG. (2013) Metabolic acclimation to excess light intensity in Chlamydomonas reinhardtii. Plant, Cell & Environment 36(7), 1391–1405. Kind T, Kwang-Hyeon L, DeFelice B, Meissen JK and Fiehn O. (2013) LipidBlast in silico tandem mass spectrometry database for lipid identification. Nature Methods 10, 755-758. Kind, T. ; Meissen, J. K. ; Yang, D. ; Nocito, F. ; Vaniya, A. ; Cheng, Y. S. ; VanderGheynst, J. S. ; Fiehn, O. (2012) Qualitative analysis of algal secretions with multiple mass spectrometric platforms. Journal of Chromatography A 1244: 139-47 Botanga, CJ, Bethke G, Chen Z, Gallie DR, Fiehn O and Glazebrook J. (2012) Metabolite profiling of Arabidopsis inoculated with Alternaria brassicicola reveals that ascorbate reduces disease severity. Molecular Plant-Microbe Interactions. 25(12),1628-1638. Yang D, Zhang Y, Barupal DK, Fan X, Gustafson R, Gua R and Fiehn O. Metabolomics of Photobiological Hydrogen Production Induced by CCCP in Chlamydomonas reinhardtii. (2014) International Journal of Hydrogen Production 39 (150-158) Botanga, Christopher J., Gerit Bethke, Zhong Chen, Daniel R. Gallie, Oliver Fiehn, and Jane Glazebrook. "Metabolite profiling of Arabidopsis inoculated with Alternaria brassicicola reveals that ascorbate reduces disease severity."Molecular Plant-Microbe Interactions 25, no. 12 (2012): 1628-1638. Meissen JK, Yuen B, Kind T, Riggs W, Barupal DK, Knoepfler PS and Fiehn O (2012) Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PloS one , 7 (10): e46770. Ogawa T., Furuhashi T, Okazawa A, Nakai R, Nakazawa M, Kind T, Fiehn O, Kanaya S, Arita M and Ohta D. Exploration of polar lipid accumulation profiles in Euglena gracilis using LipidBlast, an in-silico constructed MS/MS spectral library. Bioscience, Biotechnology, and Biochemistry Accepted, ahead-of-print (2014): 1-5) Higgins BT, VanderGheynst JS. Effects of bacterial contamination on mixotrophic growth of Chlorella minutissima and production of biofuel precursors. Biotechnology and Bioengineering. Tanadul O, VanderGheynst JS, Beckles DM, Powell ALT and Labavitch JM. The impact of elevated CO2 concentration on the quality of algal starch as a biofuel feedstock. Biotechnology and Bioengineering (accpepted; 2014) Lorena Fernández L, Cheng Y-S, Scher H and VanderGheynst JS. Managing the cultivation and processing of microalgae to prolong storage in water-in-oil emulsions. Applied Microbiology and Biotechnology Applied microbiology and biotechnology (2014): 1-7. Yang D Ma Y Conference presentations under the NSF-JST program MCB 1139644 Palazoglu, M. ; Aronova, S. ; Fiehn, O. (2012) Exploring GC-QTOF mass spectrometry workflow for identification of unknowns. 60th American Society for Mass Spectrometry Conference, Vancouver, BC, May 19 – 24, 2012. Gustafson R, Yang D, Fiehn O (2012) Functional analysis of the methyl jasmonate signaling pathway in the green alga Chlamydomonas reinhardtii. 8th Annual International Meeting of the Metabolomics Society, Washington, DC, June 25-28, 2012 Brendan Higgins, Lauren Jabusch, Yu-Shen Cheng and Jean VanderGheynst. (2012) Effects of bacterial contamination on mixotrophic growth of chlorella for biofuel production. Presented at the 2nd International Conference on Algal Biomass, Biofuels and Bioproducts. San Diego, CA. June 10-13, 2012. Brian Gong, Lauren Jabusch, Brendan Higgins and Jean VanderGheynst. (2012) Lipid and starch production in algae cultivated in winery waste water. Presented at the 3rd Annual CREATE-REU Symposium. UC Davis. August 17, 2012. Kara Johnson, Brendan Higgins, Christopher Simmons and Jean VanderGheynst. (2012) Identification of pyruvate formate lyase gene in Chlorella minutissima. Presented at the 3rd Annual CREATE-REU Symposium. UC Davis. August 17, 2012. Gabriel Vahí Ferguson, Reid Gustafson, Brendan Higgins, Oliver Fiehn and Jean VanderGheynst. (2012) Metabolite analysis of the green algae Chlorella minutissima under varying concentrations of glycerol. Presented at the 3rd Annual CREATE-REU Symposium. UC Davis. August 17, 2012. Tietel Z; Takeuchi K; Palazoglu M; Fiehn O (2013) Untargeted metabolomic analysis of UV stress response in Chlamydomonas reinhardtii using GC-QTOF and GC-TOF mass spectrometry 61st American Society for Mass Spectrometry Conference , June 9 - 13, 2013, Minneapolis, MN.