个人简介

Appointed to UC Davis faculty (1999) NIH Postdoctoral Fellowship (1993-94) Cancer Research Coordinating Committee Fellowship (1993-94) Ph.D. in Biochemistry, University of California, Berkeley (1990) B.S. in Chemistry, University of Alabama (1985)

研究领域

Biophysical Chemistry/Chemical Biology/Organic Chemistry

We are interested in both the fundamental and applied aspects of enzyme reaction mechanisms. Enzymes can catalyze reactions by enourmous factors. The sources of the great cataclyic powers of enzymes are generally understood in qualitative terms. These include close approximation of reacting groups in the enzyme substrate complex, general acid base catalysts and so on. A quantitative understanding of these catalytic tools is not available and is one of the goals of our research program. On the applied side, enzymes are often the target of pharmaceuticals. We choose to explore the mechanisms of enzymes that are promising drug targets with the ultimate goal of developing lead compounds for pharmaceutical development.

近期论文

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NMR Studies of Protonation and Hydrogen Bond States of Internal Aldimines of Pyridoxal 5'-Phosphate Acid-Base in Alanine Racemase, Aspartate Aminotransferase, and Poly-l-lysine. Chan-Huot M, Dos A, Zander R, Sharif S, Tolstoy PM, Compton S, Fogle E, Toney MD, Shenderovich I, Denisov GS, Limbach HH. J Am Chem Soc. 2013 Janus: prediction and ranking of mutations required for functional interconversion of enzymes. Addington TA, Mertz RW, Siegel JB, Thompson JM, Fisher AJ, Filkov V, Fleischman NM, Suen AA, Zhang C, Toney MD. J Mol Biol. 2013. Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase. Toney MD, Castro JN, Addington TA. J Am Chem Soc. 2013.