个人简介

Education and Degree(s) Postdoc, Applied Theoretical Chemistry, Cornell (2000-2003) PhD, Organic Chemistry, UCLA (2000) AB, Chemistry, Harvard (1995) Experience 2011-present Professor, Department of Chemistry, University of California, Davis 2008-2011 Associate Professor, Department of Chemistry, University of California, Davis 2003-2008 Assistant Professor, Department of Chemistry, University of California, Davis 2005-present Departmental advisor for organic chemistry graduate students, member Graduate Affairs Committee 2018-present Vice Chair (Academic Affairs), Department of Chemistry, UC Davis 2022-2024 VIce Chair then Chair, Coordinating Committee on Graduate Affairs (CCGA), UC Academic Senate 2020-2022 Chair, Graduate Council, UC Davis 2017-2019 Associate Editor, ACS Omega 2008-2016 Chair, R. Bryan Miller Symposium Organizing Committee 2000-2003Postdoctoral Associate, Department of Chemistry and Chemical Biology, Cornell University, with Roald Hoffmann 1998-2000 Graduate Research Assistant, Department of Chemistry and Biochemistry, UCLA, with Ken Houk 1997-2000 Teaching Fellow, Department of Chemistry and Biochemistry, UCLA 1998-1999 Fellow, Collegium of University Teaching Fellows, UCLA 1998 Instructor, Mathematics and Science Scholars Program (MS2) Pre-Instruction in Science and Mathematics (PRISM), UCLA 1996-1998Fellow, NIH Chemistry-Biology Interface Training Program, UCLA 1995-1996 Teaching Assistant, Department of Chemistry and Biochemistry, UCLA 1995 Teaching Assistant, Harvard University Summer School 1994-1995 Research Assistant, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, with James Hogle

研究领域

Chemical Biology/Organic Chemistry/Theoretical Chemistry

Research in the Tantillo group is driven by puzzling mechanistic questions. The group is particularly interested in elucidating the origins of low activation barriers and high regio- and stereoselectivities for various cascade polycyclization reactions used by Nature and by organic chemists to synthesize complex natural products, non-statistical dynamic effects and effects of entropy on selectivity of reactions occurring on both ground state and excited state surfaces, and applying quantum chemical predictions of NMR spectra to structure elucidation.

近期论文

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Guo, W.; Hare, S. R.; Chen. S.-S.; Saunders, C.; Tantillo, D. J. J. Am. Chem. Soc. 2022, 144, 17219-17231: "C-H Insertion in Dirhodium Tetracarboxylate-Catalyzed Reactions despite Dynamical Tendencies Toward Fragmentation: Implications for Reaction Efficiency and Catalyst Design” Tantillo, D. J. American Scientist 2019, 107, 22-23: "Wiggling and Jiggling" Tantillo, D. J. Chem. Soc. Rev. 2018, 47, 7845-7850: "Questions in Natural Products Synthesis Research that Can (and Cannot) be Answered Using Computational Chemistry" Tantillo, D. J. Angew. Chem. Int. Ed. 2017, 56, 10040-10045: "Importance of Inherent Substrate Reactivity in Enzyme Promoted Carbocation Cyclization/Rearrangements" Hong, Y. J.; Tantillo, D. J. Nature Chem. 2014, 6, 104-111: "Biosynthetic Consequences of Multiple Sequential Post-Transition State Bifurcations" Nguyen, Q. N. N.; Tantillo, D. J. Chem. Asian J. 2014, 9, 674-680: "The Many Roles of Quantum Chemical Predictions in Synthetic Organic Chemistry" Lodewyk, M. W.; Soldi, C.; Jones, P. B.; Olmstead, M. M.; Larrucea, J. R.; Shaw, J. T.; Tantillo, D. J. J. Am. Chem. Soc. 2012, 134, 18550-18553: "The Correct Structure of Aquatolide - Experimental Validation of a Theoretically-Predicted Structural Revision" Wedler, H. B.; Cohen, S. R.; Davis, R. L.; Harrison, J. G.; Siebert, M. R.; Willenbring, D.; Hamann, C. S.; Shaw, J. T.; Tantillo, D. J. J. Chem. Educ. 2012, 89, 1400-1404: "Computational Chemistry for the Blind and Visually Impaired" Zu, L.; Xu, M.; Lodewyk, M. W.; Cane, D. E.; Peters, R. J.; Tantillo, D. J. J. Am. Chem. Soc. 2012, 134, 11369-11371: "Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase - Support for a Mechanism Predicted by Quantum Chemistry" Tantillo, D. J. Nat. Prod. Rep. 2011, 28, 1035-1053: "Biosynthesis via Carbocations: Theoretical Studies on Terpene Formation"